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Oral glucose intake inhibits hypothalamic neuronal activity more effectively than glucose infusion

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Author: Smeets, P.A.M. · Vidarsdottir, S. · Graaf, C. de · Stafleu, A. · Osch, M.J.P. van · Viergever, M.A. · Pijl, H. · Grond, J. van der
Type:article
Date:2007
Institution: TNO Kwaliteit van Leven
Source:American Journal of Physiology - Endocrinology and Metabolism, 3, 293
Identifier: 240154
doi: doi:10.1152/ajpendo.00231.2007
Keywords: Biology · Food and Chemical Risk Analysis · Functional magnetic resonance imaging · Glucose homeostasis · Incretins · Insulin · gastrointestinal polypeptide · glucose · adult · article · controlled study · glucose blood level · glucose infusion · human · hunger · hypothalamus · insulin release · male · nerve cell · nerve conduction · normal human · nuclear magnetic resonance imaging · oral glucose tolerance test · oxygen blood level · priority journal · Action Potentials · Administration, Oral · Adult · Dose-Response Relationship, Drug · Glucose · Humans · Hypothalamus · Infusions, Intravenous · Male · Neural Inhibition · Neurons

Abstract

We previously showed that hypothalamic neuronal activity, as measured by the blood oxygen level-dependent (BOLD) functional MRI signal, declines in response to oral glucose intake. To further explore the mechanism driving changes in hypothalamic neuronal activity in response to an oral glucose load, we here compare hypothalamic BOLD signal changes subsequent to an oral vs. an intravenous (iv) glucose challenge in healthy humans. Seven healthy, normal-weight men received four interventions in random order after an overnight fast: 1) ingestion of glucose solution (75 g in 300 ml) or 2) water (300 ml), and 3) iv infusion of 40% glucose solution (0.5 g/kg body wt, maximum 35 g) or 4) infusion of saline (0.9% NaCl, equal volume). The BOLD signal was recorded as of 8 min prior to intervention (baseline) until 30 min after. Glucose infusion was associated with a modest and transient signal decline in the hypothalamus. In contrast, glucose ingestion was followed by a profound and persistent signal decrease despite the fact that plasma glucose levels were almost threefold lower than in response to iv administration. Accordingly, glucose ingestion tended to suppress hunger more than iv infusion (P < 0.1). We infer that neural and endocrine signals emanating from the gastrointestinal tract are critical for the hypothalamic response to nutrient ingestion. Copyright © 2007 the American Physiological Society.