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Effect of nondigestible oligosaccharides on large-bowel functions, blood lipid concentrations and glucose absorption in young healthy male subjects

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Author: Dokkum, W. van · Wezendonk, B. · Srikumar, T.S. · Heuvel, E.G.H.M. van den
Type:article
Date:1999
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:European Journal of Clinical Nutrition, 1, 53, 1-7
Identifier: 234921
Keywords: Nutrition · Blood lipids · Bowel function · Faecal parameters · Glucose absorption · Humans · Oligosaccharides · Acetic acid · Beta glucuronidase · Bile acid · Deoxycholic acid · Enzyme · Fructose oligosaccharide · Glucose · Inulin · Lipid · Oligosaccharide · Short chain fatty acid · Valeric acid · Adult · Clinical trial · Controlled clinical trial · Controlled study · Double blind procedure · Feces analysis · Glucose absorption · Human · Human experiment · Intestine function · Large intestine · Latin square design · Lipid blood level · Male · Normal human · PH · Randomized controlled trial · Statistical analysis · Beta-Glucosidase · Blood Chemical Analysis · Dietary Fiber · Double-Blind Method · Eating · Feces · Glucose · Glucose Tolerance Test · Glucuronidase · Humans · Intestinal Absorption · Intestine, Large · Lipids · Oligosaccharides · Questionnaires · Tryptophanase · Urease

Abstract

Objective: To study the effect of the intake of 15 g nondigestible oligosaccharides per day on various parameters of large-bowel function, as well as on blood lipid concentrations and glucose absorption in man. Design: Latin square, randomized, double-blind, diet-controlled. Setting: Metabolic research unit. Subjects: Twelve apparently healthy men (mean age 23 years), recruited from the Institute's pool of volunteers, no drop-outs. Interventions: Four treatment periods of 3 weeks: inulin, fructo-oligosaccharides (FOS), galacto-oligosaccharides (GOS) and control; analyses of stool weight, intestinal transit, faecal pH, short-chain fatty acids, bile acids, faecal enzymes, blood lipids and glucose absorption. Results: As compared to the control treatment: higher concentration of faecal acetate (inulin and GOS, P < 0.05) and valerate (inulin, P < 0.05), significantly lower concentration of faecal deoxycholic acid (inulin and FOS, P < 0.05 and P < 0.02, respectively) and β-glucuronidase activity (inulin and GOS, P < 0.05 and P < 0.02 respectively). Other changes of faecal parameters and those of blood lipids and glucose absorption were statistically not significant. Conclusions: Results indicate that nondigestible oligosaccharides are (partly) fermented in the human colon, but in healthy young men the effects are limited. Also the consumption of 15 g nondigestible oligosaccharides does not seem to alter blood lipid concentrations and glucose absorption in our young healthy adults.