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The 5T mouse multiple myeloma model: Absence of c-myc oncogene rearrangement in early transplant generations


Author: Radl, J. · Punt, Y.A. · Enden-Vieveen, M.H.M. van den · Bentvelzen, P.A.J. · Bakkus, M.H.C. · Akker T., W. van den · Benner, R.
Institution: Instituut voor Experimentele Gerontologie TNO
Source:British Journal of Cancer, 2, 61, 276-278
Identifier: 231031
Keywords: Animal cell · Animal model · Gene rearrangement · Mouse · Nonhuman · Oncogene c myc · Animal · Autoradiography · Bone Marrow · Chromosome Mapping · DNA, Neoplasm · Female · Gene Rearrangement · Male · Mice · Mice, Inbred C57BL · Multiple Myeloma · Neoplasm Transplantation · Oncogenes · Spleen · Support, Non-U.S. Gov't


Consistent chromosomal translocations involving the c-myc cellular oncogene and one of the three immunoglobulin loci are typical for human Burkitt's lymphoma, induced mouse plasmacytoma (MPC) and spontaneously arising rat immunocytoma (RIC). Another plasma cell malignancy, multiple myeloma (MM), arising spontaneously in the ageing C57BL/KaLwRij mice, was investigated in order to see whether the MM cells contain c-myc abnormalities of the MPC or RIC type. Rearrangement of the c-myc oncogene was found in the bone marrow cells only in 5T2 MM transplantation line in a mouse of the 24th generation and in none of the seven other MM of the 5T series which were of earlier generations. Since the mouse 5T MM resembles the human MM very closely, including the absence of consistent structural c-myc oncogene abnormalities, it can serve as a useful experimental model for studies on the aetiopathogenesis of this disease.