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Innate, adaptive and regulatory responses in schistosomiasis: Relationship to allergy

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Author: Hartgers, F.C. · Smits, H.H. · Kleij, D. van der · Yazdanbakhsh, M.
Type:article
Date:2006
Institution: TNO Defensie en Veiligheid
Source:Chemical Immunology and Allergy, 90, 157-175
Identifier: 183153
Keywords: Anthelmintic agent · Immunoglobulin G4 · Intercellular adhesion molecule 3 · Interleukin 13 receptor · Pattern recognition receptor · STAT1 protein · Tetanus toxoid · Toll like receptor 1 · Toll like receptor 3 · Toll like receptor 5 · Toll like receptor 6 · Toll like receptor 7 · Toll like receptor 8 · Allergy · Antibody production · Antigen specificity · Atopy · Brugia malayi · CD4+ CD25+ T lymphocyte · Cellular immunity · Chronic disease · Clonal anergy · Cross tolerance · Dendritic cell · Down regulation · Endemic disease · Helicobacter pylori · Helminthiasis · Human · Immune deficiency · Immune response · Immunoregulation · Inflammation · Innate immunity · Lymphocyte proliferation · Mast cell degranulation · Molecular interaction · Nippostrongylus brasiliensis · Nonhuman · Regulatory T lymphocyte · Review · Schistosoma · Schistosoma hematobium · Schistosoma mansoni · Schistosomiasis · Sensitization · T lymphocyte activation · T lymphocyte subpopulation · Tetanus · Th1 cell · Th2 cell · Upregulation · Animals · Chronic Disease · Hypersensitivity · Immune Tolerance · Immunity, Natural · Interleukin 13, 148157-34-0 · Tetanus toxoid, 57425-69-1, 93384-51-1 · Toll like receptor 2, 203811-81-8 · Toll like receptor 4, 203811-83-0 · Toll like receptor 9, 352486-49-8, 390883-32-6 · Toll like receptor, 409141-78-2

Abstract

Helminth infections have profound effects on the immune system. Here, recent insights in the molecular interactions between schistosomes and the host are described with respect to adaptive but also with respect to innate immune responses. Furthermore, the different mechanisms of immune hyporesponsiveness are depicted with emphasis on regulatory T cells. Finally, the relationship between downregulatory responses and allergy is discussed. Copyright © 2006 S. Karger AG.