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CD40-CD40L interactions in atherosclerosis

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Author: Laman, J.D. · Meurs, M. van · Smet, B.J.G.L. de · Schoneveld, A.
Institution: TNO Preventie en Gezondheid
Source:Immunology Today, 6, 18, 272-277
Identifier: 233928
Keywords: Health · Cd40 antigen · Glycoprotein gp 39 · Atherosclerotic plaque · Immunology · T lymphocyte activation · Animals · Antigens, CD40 · Arteriosclerosis · CD40 Ligand · Humans · Ligands · Membrane Glycoproteins · Protein Binding


The abundant presence of macrophages and activated T cells in atherosclerotic plaques suggests an active involvement of the immune system in this cardiovascular disease. However, insight into cellular interactions inducing relevant effector functions is still limited. Here, Jon Laman and colleagues propose that local interactions between CD40 and CD40 ligand may induce multiple activities by different cell types contributing to atherosclerosis. Chemicals/CAS: Antigens, CD40; CD40 Ligand, 147205-72-9; Ligands; Membrane Glycoproteins