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Genotoxicity evaluation of wood-derived and vegetable oil-derived stanol esters

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Author: Turnbull, D. · Frankos, V.H. · Delft, J.H.M. van · Vogel, N. de
Institution: Centraal Instituut voor Voedingsonderzoek TNO
Source:Regulatory Toxicology and Pharmacology, 2 I, 29, 205-210
Identifier: 235065
doi: doi:10.1006/rtph.1999.1289
Keywords: Nutrition · Fatty acid ester · Vegetable oil · Chemical structure · Chromosome aberration · Food safety · Gene mutation · Genotoxicity · Mammal cell · Priority journal · Salmonella typhimurium · Wood · Animals · Carcinogenicity Tests · CHO Cells · Chromosome Aberrations · Cricetinae · DNA Mutational Analysis · Evaluation Studies · Mice · Mutagens · Phytosterols · Plant Oils · Salmonella typhimurium · Tumor Cells, Cultured · Wood · Bacteria (microorganisms) · Mammalia · Salmonella typhimurium · Typhimurium


Plant stanol esters from wood and vegetable oil sources were tested for genotoxicity in bacterial (Salmonella typhimurium) and mammalian cell (L5178Y) gene mutation assays and in a mammalian cell chromosome aberration assay (CHO cells). The two stanol ester formulations were tested separately at doses up to the limit of solubility, with and without the addition of an Aroclor-induced rat liver microsome metabolic activation system (S9 mix). All tests were performed in duplicate and gave negative results for both wood and vegetable oil stanol ester formulations. Thus, plant stanol esters are not genotoxic under the conditions of exposure tested.