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Effect of strenuous exercise on fibrinogen and fibrinolysis in healthy elderly men and women

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Author: Schuit, A.J. · Schouten, E.G. · Kluft, C. · Maat, M. de · Menheere, P.P.C.A. · Kok, F.J.
Type:article
Date:1997
Institution: Gaubius Instituut TNO
Source:Thrombosis and Haemostasis, 2, 78, 845-851
Identifier: 233992
doi: doi:10.1055/s-0038-1657639
Keywords: Biology · acute phase protein · c reactive protein · insulin · plasminogen activator inhibitor 1 · tissue plasminogen activator · triacylglycerol · adult · aging · blood level · controlled study · exercise · female · fibrinogen blood level · human experiment · insulin blood level · normal human · thrombosis · training · triacylglycerol blood level · Aged · Aged, 80 and over · Body Weight · Exercise · Female · Fibrinogen · Fibrinolysis · Humans · Male · Middle Aged

Abstract

The elevated incidence of thrombotic disease in elderly people may be associated with an increase in PAI-1 and fibrinogen with ageing. Cross-sectional studies report an inverse relation of PAI-1 and fibrinogen with physical activity, but training studies show inconsistent results. In a controlled intervention study among elderly subjects (aged 60-80 years) we observed a moderate decrease in PAI-1 antigen (4%, -2.1 ± 2.4 ng/ml), a significant increase in t-PA activity (11%, 0.07 ± 0.04 IU/ml) and an unexpected significant increase in fibrinogen (6%, 0.18 ± 0.07 g/l) in subjects following a 6-month intensive training program as compared to controls. Reduction in PAI-1 antigen was significantly associated with a decrease in triglycerides (β = 10.3 ng/ml per 1 mM, p < 0.01) and insulin (β = 2.37 ng/ml per 1 mU/l, p = 0.07). Increase in fibrinogen coincided with a rise in C-reactive protein (p < 0.001). These data suggest that regular intensive activity may increase fibrinolytic activity in a moderate way, but also may cause chronically elevated plasma levels of acute phase proteins in elderly persons. Copyright © 1997 Schattauer Verlag