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General aspects of immunotoxicology including validation issues

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Author: Frieke Kuper, C.
Institution: TNO Kwaliteit van Leven
Source:Experimental and Toxicologic Pathology, 5-6, 57, 363-366
Identifier: 239364
doi: doi:10.1016/j.etp.2006.03.007
Keywords: Biology · Toxicology and Applied Pharmacology · Immunopathology · Organ sampling · Validation · allergy · article · autoimmune disease · histology · histopathology · human · immunotoxicity · immunotoxicology · lymphoid cell · lymphoid organ · lymphoid tissue · sensitivity and specificity · thymus · toxicology · validation study · Animals · Immune System · Immunosuppressive Agents · Lymphoid Tissue · Reproducibility of Results · Toxicity Tests · Xenobiotics


Histologic examination of lymphoid organs has revealed immunotoxic effects of a broad range of substances. The thymus has proven especially sensitive. The relative lack of sensitivity of mucosa-associated lymphoid cells and tissues may be due to shortcomings in the way they are examined. Validation of ways to examine mucosal lymphoid tissues and cells and development of histopathological tools to flag a compound as a potential inducer of autoimmune disease or allergy are challenges for the future. © 2006 Elsevier GmbH. All rights reserved.