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Lost in translation? Role of metabolomics in solving translational problems in drug discovery and development

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Author: Greef, J. van der · Adourian, A. · Muntendam, P. · McBurney, R.N.
Institution: TNO Kwaliteit van Leven
Source:Drug Discovery Today: Technologies, 2, 3, 205-211
Identifier: 239279
doi: doi:10.1016/j.ddtec.2006.05.003
Keywords: Biology · Analytical research · biological marker · drug metabolite · new drug · bioinformatics · body fluid · data base · decision making · drug determination · drug efficacy · drug marketing · drug research · drug safety · human · medical technology · metabolomics · multiple sclerosis · non insulin dependent diabetes mellitus · nonhuman · osteoarthritis · phenotype · postmarketing surveillance · proteomics · review · serology · structure activity relation


Too few drug discovery projects generate a marketed drug product, often because preclinical studies fail to predict the clinical experience with a drug candidate. Improving the success of preclinical-to-clinical translation is of paramount importance in optimizing the pharmaceutical value chain. Here, we advance the case for a molecular systems approach to crossing the preclinical-to-clinical translational chasm and for metabolomic analysis of readily accessible bodyfluids as a key technology in translational activities. © 2006.