Mobile and wireless communication systems are becoming more and more complex, making understanding the interaction of different technologies on different layers a very difficult task. The introduction of sophisticated techniques on the physical layer that react to changes of the wireless channel on small timescales requires new paradigms for modeling, simulating, and analyzing current and future wireless networks. Investigating the relationship of new physical layer techniques, application-specific requirements and performance measures will become a major research topic for future wireless networks. A continuous change in the methodology for evaluating the network performance takes place in the Internet. In the past, network performance was mainly evaluated using concretely measurable values like packet loss rate, delay, or jitter. The current trend in the Internet goes toward application-specific quality measures that judge more the subjective experience of the end user than they do network parameters. In the terminology, this is expressed as the change from quality of service (QoS-Quality of Service (QoS)) to quality of experience (QoE). For wireless networks this leads to interesting consequences, as currently the traffic requirements for MAC layer connections are mainly formulated in terms of QoS parameters. Accomplishing the change from QoS to QoE also in the definition of connection parameters is a future challenge for wireless networks, for which the first approaches are presented.