We investigated the effect of the eggplant core on the plasma concentrations of triglycerides, total- LDL- and HDL-cholesterol, in male guinea pigs, randomly assigned into five groups: 1 (N) - normolipidic diet AIN-93G, 2 (NB) - normolipidic diet, supplemented with eggplant core, halfway of the experiment, 3 (H) - hyperlipidic diet (AIN-93G modified), with 0.16% of cholesterol and 7% of coconut fat, 4 (HB) - diet from group 3, supplemented with eggplant core halfway of the experiment, 5 (HNB) - hyperlipidic diet, replaced by the normolipidic diet with eggplant core, halfway of the experiment. The animals plasma was collected at the 0, 16 and 32nd days of the experiment. Supplementation of eggplant core, from the 16th day of the experiment on, reduced total cholesterol, HDL- and LDL-cholesterol concentrations, in groups HB and HNB. At the end of the experiment, no statistically significant difference in the plasma concentrations of triglycerides and VLDL-cholesterol was observed between the five groups of animals. In the animals from group NB, the supplementation of the eggplant core did not influence plasma levels of total cholesterol and HDL- and LDL-cholesterol, indicating the absence of effects from eggplant core when the plasma concentrations of total and LDL-cholesterol are not elevated. The addition of eggplant core, which means a change from a hyperlipidic and hypercholesterolemic diet to a normolipidic diet provided a higher reduction of the plasma levels of total and LDL-cholesterol of the studied animals. The results of the current research indicate clearly the benefits of the supplementation of the eggplant core, with or without diet changing, over the plasmatic concentration of the guinea pigs' total cholesterol and LDL cholesterol. Perspectives on the use of the eggplant core in humans to reduce the total cholesterol and the LDL cholesterol must be considered, because, although the lipoprotein HDL level was reduced, a much more significant diminishing of plasmatic total cholesterol and LDL cholesterol was obtained.