Print Email Facebook Twitter Sol–gel one-pot synthesis in soft conditions of mesoporous silica materials ready for drug delivery system Title Sol–gel one-pot synthesis in soft conditions of mesoporous silica materials ready for drug delivery system Author Tourne-Peteilh, C. Begu, S. Lerner, D.A. Galarneau, A. Lafont, U. Devoiselle, J.M. Faculty Applied Sciences Department Nanostructured Materials Date 2011-12-13 Abstract The present work reveals a new and simple strategy, a one-step sol–gel procedure, to encapsulate a low water-soluble drug in silica mesostructured microparticles and to improve its release in physiological media. The synthesis of these new materials is based on the efficient solubilisation of a poorly water-soluble drug in surfactant micelles (Tween 80, a pharmaceutical excipient) which act as template for the silica network. A strict control of the sol–gel process and the parameters procedure in soft conditions (concentration, pH, temperature) was applied to reach the solubilisation limit of the drug in the micellar solution so as to optimise its encapsulation. Even if this one-pot procedure could appear limited by the low drug loading, it could provide an interesting alternative for the formulation of many recent highly active but very poorly soluble drugs. Subject drug deliverysolgeltemplatingibuprofentween 80 To reference this document use: http://resolver.tudelft.nl/uuid:096186de-c97b-4202-bcba-7cfc7d5d0a0c DOI https://doi.org/10.1007/s10971-011-2646-x Publisher Springer ISSN 0928-0707 Source http://www.springerlink.com/content/t501372hg3710627/ Source Journal of sol-gel science and technology, 61(3)2012 Part of collection Institutional Repository Document type journal article Rights (c)2012 The Authors, Springer-Verlag Files PDF 2012-49Tourne.pdf 455.41 KB Close viewer /islandora/object/uuid:096186de-c97b-4202-bcba-7cfc7d5d0a0c/datastream/OBJ/view