To keep patients mobile and to treat injuries to improve the quality of life, functional biomaterials for implants and prosthesis are designed. Apart from growing demand in orthopaedic replacement and trauma surgeries, the number of revisions surgeries is increasing as well. Revisions surgeries are performed after the life-time of the implant has exceeded, but also due to implant failure. The latter is mainly caused by mechanical failure. Metallic glasses form a promising class of metallic materials possessing an amorphous structure. When such an alloy can be formed in rods over 1 mm in diameter, it is called a bulk metallic glass (BMG). Compared to the currently used crystalline alloys, BMGs possess several beneficial mechanical properties over the currently applied crystalline biomaterials. Next to mechanical failure, implant loosening by lack of osseointegration and an implant associated infection (IAI) are a reason for necessary revision. In the US, 2% joint prostheses and 5% of fracturefixation devices become infected. After bone implantation, there is a competition in the colonisation of the implant by human bone cells and bacteria, in which the surface morphology and biochemistry have influence. Predominantly S. aureus cause IAI. In most cases, antibiotics are effective, but there is a rising incidence in stems, like methicillin-resistant S. aureus (MRSA), resistant to commonly used antibiotics. A local general antiseptic effect from the implant material is desired. There is a rising interest for the use of silver nanoparticles (AgNPs), which a potent bactericidal effect, while the cytotoxicity is low to mammalian cells. Also desired is improved osteointegration sought after by a large specific surface area that is osteoconductive. Plasma electrolytic oxidation (PEO) can create a firmly adhered coating with high porosity on some materials. AgNPs in a PEO coating on BMGs is a strategy to reduce revision surgeries by better mechanical properties, improved osteointegration, and protection against IAI. The synthesis of a multi-functional PEO coating on Ti- and Zr- based BMGs is described by a total approach. Ni and Be-free BMGs were produced in cooperation with the ETH Zürich of nominal compositions; Zr60.5Cu10.2Al8.9Fe10.2Ag9.7Ti0.5 (Zr605), Zr62.5Cu22.5Al10Fe5 (Zr625), and Ti47Zr7.5Cu38-Fe2.5Ag2Sn2Si1 (Ti47). A PEO coating was successfully made on BMGs with a DC power supply in combined galvanostatic and potentiostatic mode of 4 A and 350 V, respectively. Incorporation of Ag-NPs in the coating was achieved, confirmed with EDS. The surface morphology was characterised with XRD, SEM and EDS. The viability of MC3T3-E1 pre-osteoblasts was confirmed on the untreated, PEO treated BMGs, and PEO treated with AgNPs. Moreover, the antibacterial effect of the PEO coated BMGs with AgNPs against MRSA was demonstrated in vitro by a zone of inhibition in an agar leaching assay. Ag-containing BMGs has a small zone of inhibition as well after PEO treatment. Probably, there is a (synergistic) bactericidal effect with Cu and Ag, deduced from the ion release kinetics in PBS measured by ICP-OES. From initial tests, the strategy of a multi-functional coating to reduce revision surgeries and improve the quality of life for patients holds promise. The described PEO process with DC could be a starting point from where PEO coating on BMG coatings can be optimised. The mechanical performance, especially the fatigue endurance with and without coating, should be assessed. The in vitro and biological performance of should be extensively evaluated before proceeding to in vivo experiments.