A mean 4-year evaluation of infection control rates of hip and knee prosthetic joint infection-related revision arthroplasty

A mean 4-year evaluation of infection control rates of hip and knee prosthetic joint infection-related revision arthroplasty: an observational study

van Dijk, Bruce (University Medical Center Utrecht)
Nurmohamed, F. Ruben H.A. (University Medical Center Utrecht)
Hooning van Duyvenbode, J. Fred F. (University Medical Center Utrecht)
Veltman, Ewout S. (University Medical Center Utrecht)
Rentenaar, Rob J. (University Medical Center Utrecht)
Weinans, Harrie (TU Delft Biomaterials & Tissue Biomechanics; University Medical Center Utrecht)
Vogely, H. Charles (University Medical Center Utrecht)
van der Wal, Bart C.H. (University Medical Center Utrecht)

2022

Background and purpose — The long-term results of the 1-or 2-stage revision procedure and infection-free prosthesis survival in a tertiary referral center are unknown. In this retrospective observational study, the long-term results of infection control and infection-free prosthesis survival of the peri-prosthetic joint infection-related 1-and 2-stage revision procedure are evaluated. Furthermore, the merits of performing an antibiotic-free window in the 2-stage revision is evaluated. Patients and methods — All patients who received a 1-or 2-stage revision procedure of the hip or knee between 2010 and 2017 were included. Data was collected on patient and infection characteristics. The primary treatment aim was successful infection control without the use of antibiotic therapy afterwards. Infection-free survival analysis was performed using the Kaplan–Meier method with type of periprosthetic joint infection-related revision as covariate. Within the group of 2-stage revisions, use of an antibiotic-free window was selected as covariate. Results — 128 patients were treated for a periprosthetic joint infection-related revision procedure (81 hips and 47 knees). Successful infection control was achieved in 18 of 21 cases for the 1-stage and 89 out of 107 cases for the 2-stage revision procedure (83%) respectively after follow-up of more than 4 years. In addition, 2-stage revision procedure infection control was achieved in 52 of 60 cases with an anti-biotic-free interval and 37 of 45 cases without such interval (p = 0.6). The mean infection-free survival of the 1-stage revision was 90 months (95% CI 75–105) and 98 months (CI 90–106) for the 2-stage revision procedure. Interpretation — There seems to be no difference in infection control and infection-free survival between the 1-and 2-stage revision procedure. Second, an antibiotic-free window in the case of a 2-stage revision did not seem to influence treatment outcome. However, one must be cautious when interpreting these results due to confounding by indication and the small study population. Therefore, no definite conclusion can be drawn.

http://resolver.tudelft.nl/uuid:28458d93-9b4b-4825-85f6-1a3396200eb7

https://doi.org/10.2340/17453674.2022.3975

1745-3674

Acta orthopaedica, 93, 652-657

Institutional Repository

journal article

© 2022 Bruce van Dijk, F. Ruben H.A. Nurmohamed, J. Fred F. Hooning van Duyvenbode, Ewout S. Veltman, Rob J. Rentenaar, Harrie Weinans, H. Charles Vogely, Bart C.H. van der Wal