Print Email Facebook Twitter A 3D microelectrode array to record neural activity at different tissue depths Title A 3D microelectrode array to record neural activity at different tissue depths Author de Rijk, T.M. (Student TU Delft) Hu, Michel (Leiden University Medical Center) Frimat, Jean-Philippe (Leiden University Medical Center) van den Maagdenberg, Arn M.J.M. (Leiden University Medical Center) Sarro, Pasqualina M (TU Delft Electronic Components, Technology and Materials) Mastrangeli, Massimo (TU Delft Electronic Components, Technology and Materials) Date 2020 Abstract In vitro study of high-level neurobiological systems requires three-dimensional (3D) neuronal cultures [1]. Meas-uring responses along all three spatial dimensions is critical to record electric activity inside 3D neuronal models, such as organoids and other 3D brain tissue constructs. However, this lies beyond the capacity of 2D microelec-trode arrays (MEAs) [2]. We present planar arrays of 3D micro-pyramids, whereby each micro-pyramid supports multiple, electrically distinct and vertically stacked microelectrodes. The 3D microarrays were produced by wafer-scale micromachining and assembled onto printed circuit boards (PCBs) conforming to MEA readout standards. To reference this document use: http://resolver.tudelft.nl/uuid:287eaa11-5d67-47e3-99d1-4081f0fcde1c Event European Organ-on-Chip Society Conference (EUROoCS Conference 2020), 2020-07-08 → 2020-07-09, Online Bibliographical note Virtual/online event due to COVID-19 Part of collection Institutional Repository Document type poster Rights © 2020 T.M. de Rijk, Michel Hu, Jean-Philippe Frimat, Arn M.J.M. van den Maagdenberg, Pasqualina M Sarro, Massimo Mastrangeli Files PDF deRijk_EUROoCS2020.pdf 410.67 KB Close viewer /islandora/object/uuid:287eaa11-5d67-47e3-99d1-4081f0fcde1c/datastream/OBJ/view