Print Email Facebook Twitter Advanced bredigite-containing magnesium-matrix composites for biodegradable bone implant applications Title Advanced bredigite-containing magnesium-matrix composites for biodegradable bone implant applications Author Naddaf Dezfuli, S. (TU Delft (OLD) MSE-1; TU Delft Biomaterials & Tissue Biomechanics) Huan, Z. (Chinese Academy of Sciences) Mol, J.M.C. (TU Delft (OLD) MSE-6) Leeflang, M.A. (TU Delft Biomaterials & Tissue Biomechanics) Chang, Jiang (Chinese Academy of Sciences) Zhou, J. (TU Delft Biomaterials & Tissue Biomechanics) Date 2017 Abstract The present research was aimed at developing magnesium-matrix composites that could allow effective control over their physiochemical and mechanical responses when in contact with physiological solutions. A biodegradable, bioactive ceramic - bredigite was chosen as the reinforcing phase in the composites, based on the hypothesis that the silicon- and magnesium-containing ceramic could protect magnesium from fast corrosion and at the same time stimulate cell proliferation. Methods to prepare composites with integrated microstructures - a prerequisite to achieve controlled biodegradation were developed. A systematic experimental approach was taken in order to elucidate the in vitro biodegradation mechanisms and kinetics of the composites. It was found that the composites with 20–40% homogenously dispersed bredigite particles, prepared from powders, could indeed significantly decrease the degradation rate of magnesium by up to 24 times. Slow degradation of the composites resulted in the retention of the mechanical integrity of the composites within the strength range of cortical bone after 12 days of immersion in a cell culture medium. Cell attachment, cytotoxicity and bioactivity tests confirmed the stimulatory effects of bredigite embedded in the composites on the attachment, viability and differentiation of bone marrow stromal cells. Thus, the multiple benefits of adding bredigite to magnesium in enhancing degradation behavior, mechanical properties, biocompatibility and bioactivity were obtained. The results from this research showed the excellent potential of the bredigite-containing composites for bone implant applications, thus warranting further in vitro and in vivo research. Subject BioactivityBredigiteCompositesDegradationMagnesiumMechanical properties To reference this document use: http://resolver.tudelft.nl/uuid:2b495b3e-99e8-402b-95cf-b32a6e0b0e53 DOI https://doi.org/10.1016/j.msec.2017.05.021 Embargo date 2019-05-19 ISSN 0928-4931 Source Materials Science and Engineering C: Materials for Biological Applications (online), 79, 647-660 Bibliographical note Accepted Author Manuscript Part of collection Institutional Repository Document type journal article Rights © 2017 S. Naddaf Dezfuli, Z. Huan, J.M.C. Mol, M.A. Leeflang, Jiang Chang, J. Zhou Files PDF Mg_MMCs_Mat_Sci_Eng_C.pdf 1.24 MB Close viewer /islandora/object/uuid:2b495b3e-99e8-402b-95cf-b32a6e0b0e53/datastream/OBJ/view