Print Email Facebook Twitter The Development of Tungsten Biochemistry-A Personal Recollection Title The Development of Tungsten Biochemistry-A Personal Recollection Author Hagen, W.R. (TU Delft BT/Biocatalysis) Date 2023 Abstract The development of tungsten biochemistry is sketched from the viewpoint of personal participation. Following its identification as a bio-element, a catalogue of genes, enzymes, and reactions was built up. EPR spectroscopic monitoring of redox states was, and remains, a prominent tool in attempts to understand tungstopterin-based catalysis. A paucity of pre-steady-state data remains a hindrance to overcome to this day. Tungstate transport systems have been characterized and found to be very specific for W over Mo. Additional selectivity is presented by the biosynthetic machinery for tungstopterin enzymes. Metallomics analysis of hyperthermophilic archaeon Pyrococcus furiosus indicates a comprehensive inventory of tungsten proteins. Subject aldehyde oxidoreductaseEPRmetallomicsPyrococcus furiosustransporttungstentungstoenzymetungstopterin To reference this document use: http://resolver.tudelft.nl/uuid:5cafcdd1-a878-4514-9146-a88651fcc81c DOI https://doi.org/10.3390/molecules28104017 ISSN 1420-3049 Source Molecules: a journal of synthetic organic and natural product chemistry, 28 (10) Part of collection Institutional Repository Document type review Rights © 2023 W.R. Hagen Files PDF molecules_28_04017.pdf 3.58 MB Close viewer /islandora/object/uuid:5cafcdd1-a878-4514-9146-a88651fcc81c/datastream/OBJ/view