Print Email Facebook Twitter The Correlation Between Wall Shear Stress and Plaque Composition in Advanced Human Carotid Atherosclerosis Title The Correlation Between Wall Shear Stress and Plaque Composition in Advanced Human Carotid Atherosclerosis Author Moerman, A. M. (Erasmus MC) Korteland, S. (Erasmus MC) Dilba, K. (Erasmus MC) van Gaalen, K. (Erasmus MC) Poot, D. H.J. (Erasmus MC) van Der Lugt, A. (Erasmus MC) Verhagen, H. J.M. (Erasmus MC) Wentzel, J. J. (Erasmus MC) van Der Steen, A. F.W. (Erasmus MC) Gijsen, F.J.H. (TU Delft Medical Instruments & Bio-Inspired Technology; Erasmus MC) Van der Heiden, K. (Erasmus MC) Date 2022 Abstract The role of wall shear stress (WSS) in atherosclerotic plaque development is evident, but the relation between WSS and plaque composition in advanced atherosclerosis, potentially resulting in plaque destabilization, is a topic of discussion. Using our previously developed image registration pipeline, we investigated the relation between two WSS metrics, time-averaged WSS (TAWSS) and the oscillatory shear index (OSI), and the local histologically determined plaque composition in a set of advanced human carotid plaques. Our dataset of 11 carotid endarterectomy samples yielded 87 histological cross-sections, which yielded 511 radial bins for analysis. Both TAWSS and OSI values were subdivided into patient-specific low, mid, and high tertiles. This cross-sectional study shows that necrotic core (NC) size and macrophage area are significantly larger in areas exposed to high TAWSS or low OSI. Local TAWSS and OSI tertile values were generally inversely related, as described in the literature, but other combinations were also found. Investigating the relation between plaque vulnerability features and different combinations of TAWSS and OSI tertile values revealed a significantly larger cap thickness in areas exposed to both low TAWSS and low OSI. In conclusion, our study confirmed previous findings, correlating high TAWSS to larger macrophage areas and necrotic core sizes. In addition, our study demonstrated new relations, correlating low OSI to larger macrophage areas, and a combination of low TAWSS and low OSI to larger cap thickness. Subject atherosclerosisimage registration pipelineMRIoscillatory shear indexplaque compositionvulnerable plaquewall shear stress To reference this document use: http://resolver.tudelft.nl/uuid:5e5974a7-4b7e-4cbe-be48-67f928bd2094 DOI https://doi.org/10.3389/fbioe.2021.828577 ISSN 2296-4185 Source Frontiers in Bioengineering and Biotechnology, 9 Part of collection Institutional Repository Document type journal article Rights © 2022 A. M. Moerman, S. Korteland, K. Dilba, K. van Gaalen, D. H.J. Poot, A. van Der Lugt, H. J.M. Verhagen, J. J. Wentzel, A. F.W. van Der Steen, F.J.H. Gijsen, K. Van der Heiden Files PDF fbioe_09_828577.pdf 1.34 MB Close viewer /islandora/object/uuid:5e5974a7-4b7e-4cbe-be48-67f928bd2094/datastream/OBJ/view