Print Email Facebook Twitter Adaptation of nanoarrays for the study of ?-synuclein aggregation - preliminary results Title Adaptation of nanoarrays for the study of ?-synuclein aggregation - preliminary results Author Dietrich, H.R.C. Van den Doel, R.L. Hoyer, W. Van Oel, W. Liqui Lung, G. Garini, Y. Jovin, T. Young, I.T. Faculty Applied Sciences Department Imaging Science and Technology Date 2005-03-29 Abstract In previous publications we have shown that we can perform enzymatic reactions in nanoarrays by means of a microarray-reader based on a conventional microscope. In this publication we report on a modification of this system in order to monitor the aggregation kinetics of the natively unfolded protein ?-synuclein. We describe the motivation for this development, the problems associated with the miniaturization of the aggregation assay, and the validation of our modifications. Subject nanoarrayshigh throughput screeningevaporation control?-synucleinthioflavin Tquantitative fluorescence microscopy To reference this document use: http://resolver.tudelft.nl/uuid:62daf108-7f76-4db6-9e01-49ce11ce6d37 Publisher SPIE ISSN 0277-786X Source Proceedings of SPIE, 2005 vol. 5699 Part of collection Institutional Repository Document type conference paper Rights (c)2005 Dietrich, H.R.C., Van den Doel, R.L., Hoyer, W., Van Oel, W., Liqui Lung, G., Garini, Y., Jovin, T., Young, I.T. Files PDF AdaptationHeidelinde.pdf 851.35 KB Close viewer /islandora/object/uuid:62daf108-7f76-4db6-9e01-49ce11ce6d37/datastream/OBJ/view