Print Email Facebook Twitter Groove model of tibia-femoral osteoarthritis in the rat Title Groove model of tibia-femoral osteoarthritis in the rat Author de Visser, H.M. (University Medical Center Utrecht) Weinans, Harrie (TU Delft Biomaterials & Tissue Biomechanics; University Medical Center Utrecht) Coeleveld, K. (University Medical Center Utrecht) van Rijen, M.H.P. (University Medical Center Utrecht) Lafeber, F.P.J.G. (University Medical Center Utrecht) Mastbergen, S.C. (University Medical Center Utrecht) Date 2016 Abstract Several experimental models of osteoarthritis in rats are used to study the pathophysiology of osteoarthritis. Many mechanically induced models have the limitation that permanent joint instability is induced by, for example, ligament transection or meniscal damage. This permanent instability will counteract the potential beneficial effects of therapy. The groove model of osteoarthritisuses a one-time trigger, surgically induced cartilage damage on the femoral condyles, and has been validated for the canine tibia-femoral compartment. The present study evaluates this model for the rat knee joint. The articular cartilage of the weight bearing surface of both femoral condyles and trochlea were damaged (grooved) without damaging the underlying subchondral bone. Severity of joint degeneration was histologically assessed, in addition to patella cartilage damage, and subchondral bone characteristics by means of (contrast-enhanced) micro-CT. Mild histological degeneration of the surgically untouched tibial plateau cartilage was observed in addition to damage of the femoral condyles, without clear synovial tissue inflammation. Contrast enhanced micro-CT demonstrated proteoglycan loss of the surgically untouched patella cartilage. Besides, a more sclerotic structure of the subchondral bone was observed. The tibiafemoral groove model in a rat results in mild knee joint degeneration, without permanent joint instability and joint inflammation. This makes the rat groove model a useful model to study the onset and progression of post-traumatic non-inflammatory osteoarthritis, creating a relatively sensitive model to study disease modifying osteoarthritic drugs. 2016 The Authors. Journal of Orthopaedic Research published by Wiley Periodicals, Inc. on behalf of the Orthopaedic Research Society. J Orthop Res. To reference this document use: http://resolver.tudelft.nl/uuid:6689ed4c-d382-4145-b885-ab0fc6d65d66 DOI https://doi.org/10.1002/jor.23299 ISSN 0736-0266 Source Journal of Orthopaedic Research: a journal for musculoskeletal investigation, 35 (2017) (3), 496-505 Part of collection Institutional Repository Document type journal article Rights © 2016 H.M. de Visser, Harrie Weinans, K. Coeleveld, M.H.P. van Rijen, F.P.J.G. Lafeber, S.C. Mastbergen Files PDF Visser_et_al_2016_Journal ... search.pdf 4.12 MB Close viewer /islandora/object/uuid:6689ed4c-d382-4145-b885-ab0fc6d65d66/datastream/OBJ/view