Print Email Facebook Twitter Directionality of corticomuscular coupling in essential tremor and cortical myoclonic tremor Title Directionality of corticomuscular coupling in essential tremor and cortical myoclonic tremor Author Sharifi, S. (Universiteit van Amsterdam; Amsterdam UMC) Luft, F. (University of Twente) Potgieter, S. Heida, T. (University of Twente) Mugge, W. (TU Delft Biomechatronics & Human-Machine Control) Schouten, A.C. (TU Delft Biomechatronics & Human-Machine Control) Bour, L. J. (Universiteit van Amsterdam) van Rootselaar, A. F. (Universiteit van Amsterdam; Amsterdam UMC) Date 2021 Abstract Objective: A role of the motor cortex in tremor generation in essential tremor (ET) is assumed, yet the directionality of corticomuscular coupling is unknown. Our aim is to clarify the role of the motor cortex. To this end we also study ‘familial cortical myoclonic tremor with epilepsy’ (FCMTE) and slow repetitive voluntary movements with a known cortical drive. Methods: Directionality of corticomuscular coupling (EEG-EMG) was studied with renormalized partial directed coherence (rPDC) during tremor in 25 ET patients, 25 healthy controls (mimicked) and in seven FCMTE patients; and during a self-paced 2 Hz task in eight ET patients and seven healthy controls. Results: Efferent coupling around tremor frequency was seen in 33% of ET patients, 45.5% of healthy controls, all FCMTE patients, and, around 2 Hz, in all ET patients and all healthy controls. Ascending coupling, seen in the majority of all participants, was weaker in ET than in healthy controls around 5–6 Hz. Conclusions: Possible explanations are that tremor in ET results from faulty subcortical output bypassing the motor cortex; rate-dependent transmission similar to generation of rhythmic movements; and/or faulty feedforward mechanism resulting from decreased afferent (sensory) coupling. Significance: A linear cortical drive is lacking in the majority of ET patients. Subject Corticomuscular couplingEssential tremorFCMTErPDCTremor network To reference this document use: http://resolver.tudelft.nl/uuid:6afce94b-509c-4ff0-b3d1-2d9d364405d7 DOI https://doi.org/10.1016/j.clinph.2021.04.011 ISSN 1388-2457 Source Clinical Neurophysiology, 132 (8), 1878-1886 Part of collection Institutional Repository Document type journal article Rights © 2021 S. Sharifi, F. Luft, S. Potgieter, T. Heida, W. Mugge, A.C. Schouten, L. J. Bour, A. F. van Rootselaar Files PDF 1_s2.0_S1388245721005551_main.pdf 1.05 MB Close viewer /islandora/object/uuid:6afce94b-509c-4ff0-b3d1-2d9d364405d7/datastream/OBJ/view