Print Email Facebook Twitter A model for cell migration in non-isotropic fibrin networks with an application to pancreatic tumor islets Title A model for cell migration in non-isotropic fibrin networks with an application to pancreatic tumor islets Author Chen, J. (TU Delft Numerical Analysis) Weihs, Daphne (Technion) Vermolen, F.J. (TU Delft Numerical Analysis) Date 2017 Abstract Cell migration, known as an orchestrated movement of cells, is crucially important for wound healing, tumor growth, immune response as well as other biomedical processes. This paper presents a cell-based model to describe cell migration in non-isotropic fibrin networks around pancreatic tumor islets. This migration is determined by the mechanical strain energy density as well as cytokines-driven chemotaxis. Cell displacement is modeled by solving a large system of ordinary stochastic differential equations where the stochastic parts result from random walk. The stochastic differential equations are solved by the use of the classical Euler–Maruyama method. In this paper, the influence of anisotropic stromal extracellular matrix in pancreatic tumor islets on T-lymphocytes migration in different immune systems is investigated. As a result, tumor peripheral stromal extracellular matrix impedes the immune response of T-lymphocytes through changing direction of their migration. Subject Cell migrationCell-based modelPancreatic tumor isletSemi-stochastic modelStromal extracellular matrix To reference this document use: http://resolver.tudelft.nl/uuid:6d628385-3a08-4b6e-8c73-b2e4cde246be DOI https://doi.org/10.1007/s10237-017-0966-7 ISSN 1617-7959 Source Biomechanics and Modeling in Mechanobiology (online), 17 (2018) (2), 367–386 Part of collection Institutional Repository Document type journal article Rights © 2017 J. Chen, Daphne Weihs, F.J. Vermolen Files PDF 10.1007_s10237_017_0966_7.pdf 1.47 MB Close viewer /islandora/object/uuid:6d628385-3a08-4b6e-8c73-b2e4cde246be/datastream/OBJ/view