Print Email Facebook Twitter A 256 pixel magnetoresistive biosensor microarray in 0.18μm CMOS Title A 256 pixel magnetoresistive biosensor microarray in 0.18μm CMOS Author Hall, Drew A. (Stanford University) Gaster, Richard S. (Stanford University) Makinwa, K.A.A. (TU Delft Electronic Instrumentation) Wang, Shan X. (Stanford University) Murmann, Boris (Stanford University) Date 2013 Abstract Magnetic nanotechnologies have shown significant potential in several areas of nanomedicine such as imaging, therapeutics, and early disease detection. Giant magnetoresistive spin-valve (GMR SV) sensors coupled with magnetic nanotags (MNTs) possess great promise as ultra-sensitive biosensors for diagnostics. We report an integrated sensor interface for an array of 256 GMR SV biosensors designed in 0.18 μm CMOS. Arranged like an imager, each of the 16 column level readout channels contains an analog frontend and a compact ΣΔ modulator (0.054 mm2) with 84 dB of dynamic range and an input referred noise of 49nT/√Hz. Performance is demonstrated through detection of an ovarian cancer biomarker, secretory leukocyte peptidase inhibitor (SLPI), spiked at concentrations as low as 10 fM. This system is designed as a replacementfor optical protein microarrays while also providing real-time kinetics monitoring. Subject BiochipbiosensorGMR spin-valvemagnetic biosensorproteomicssigma delta modulator To reference this document use: http://resolver.tudelft.nl/uuid:8a2d0c99-162f-479f-ad66-579176172b34 DOI https://doi.org/10.1109/JSSC.2013.2245058 ISSN 0018-9200 Source IEEE Journal of Solid State Circuits, 48 (5), 1290-1301 Bibliographical note Accepted author version Part of collection Institutional Repository Document type journal article Rights © 2013 Drew A. Hall, Richard S. Gaster, K.A.A. Makinwa, Shan X. Wang, Boris Murmann Files PDF 2049639_JSSC2245058.pdf 2.11 MB Close viewer /islandora/object/uuid:8a2d0c99-162f-479f-ad66-579176172b34/datastream/OBJ/view