Metabolic engineering of xylose fermenting eukaryotic cells

Title

Metabolic engineering of xylose fermenting eukaryotic cells

 Author

Winkler, A.A.
Kuyper, S.M.
De Laat, W.T.
Van Dijken, J.P.
Pronk, J.T.

Faculty

Applied Sciences

 Date

2006-01-26

 Abstract

The present invention relates to further genetic modifications in eukaryotic host cells that have been transformed to express a xylose isomerase that confers the host cell the ability of isomerising xylose to xylulose. The further genetic modifications are aimed at improving the efficiency of xylose metabolism and include e.g. reduction of unspecific aldose reductase activity, increased xylulose kinase activity and increased flux of the pentose phosphate pathway. The modified host cells of the invention are suitable for the production of a wide variety of fermentation products, including ethanol, in fermentation processes in which a source of xylose or a source of xylose and glucose are used as carbon source.

 To reference this document use:

http://resolver.tudelft.nl/uuid:984d3ef8-4c91-4242-acca-61d925db95d6

 Publisher

European Patent Office

 Source

http://v3.espacenet.com/publicationDetails/biblio?CC=WO&NR=2006009434A1&KC=A1&FT=D&date=20060126&DB=&locale=en_EP

 Source

WO 2006009434 (A1) CA 2861834 (A1)

 Part of collection

Institutional Repository

 Document type

patent

 Rights

(c) 2006 The Author(s)
Files
PDF WO2006009434.pdf 96.07 KB
PDF CA2861834A1.pdf 2.45 MB
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