Print Email Facebook Twitter Resilience and resistance to the accumulation of amyloid plaques and neurofibrillary tangles in centenarians Title Resilience and resistance to the accumulation of amyloid plaques and neurofibrillary tangles in centenarians: An age-continuous perspective Author Zhang, M. (TU Delft Pattern Recognition and Bioinformatics; Vrije Universiteit Amsterdam) Ganz, Andrea B. (Vrije Universiteit Amsterdam; Amsterdam UMC) Rohde, Susan (Vrije Universiteit Amsterdam; Amsterdam UMC) Rozemuller, Annemieke J.M. (Netherlands Institute for Neuroscience NIN - KNAW; Amsterdam UMC) Bank, Netherlands Brain (Netherlands Institute for Neuroscience NIN - KNAW) Reinders, M.J.T. (TU Delft Pattern Recognition and Bioinformatics) Scheltens, Philip (Vrije Universiteit Amsterdam) Hulsman, M. (TU Delft Pattern Recognition and Bioinformatics; Vrije Universiteit Amsterdam) Hoozemans, Jeroen J.M. (Amsterdam UMC) Holstege, H. (TU Delft Intelligent Systems; Vrije Universiteit Amsterdam) Department Intelligent Systems Date 2022 Abstract Introduction: With increasing age, neuropathological substrates associated with Alzheimer's disease (AD) accumulate in brains of cognitively healthy individuals—are they resilient, or resistant to AD-associated neuropathologies?. Methods: In 85 centenarian brains, we correlated NIA (amyloid) stages, Braak (neurofibrillary tangle) stages, and CERAD (neuritic plaque) scores with cognitive performance close to death as determined by Mini-Mental State Examination (MMSE) scores. We assessed centenarian brains against 2131 brains from AD patients, non-AD demented, and non-demented individuals in an age continuum ranging from 16 to 100+ years. Results: With age, brains from non-demented individuals reached the NIA and Braak stages observed in AD patients, while CERAD scores remained lower. In centenarians, NIA stages varied (22.4% were the highest stage 3), Braak stages rarely exceeded stage IV (5.9% were V), and CERAD scores rarely exceeded 2 (4.7% were 3); within these distributions, we observed no correlation with the MMSE (NIA: P = 0.60; Braak: P = 0.08; CERAD: P = 0.16). Discussion: Cognitive health can be maintained despite the accumulation of high levels of AD-related neuropathological substrates. Highlights: Cognitively healthy elderly have AD neuropathology levels similar to AD patients. AD neuropathology loads do not correlate with cognitive performance in centenarians. Some centenarians are resilient to the highest levels of AD neuropathology. Subject agingAlzheimer's diseasecentenarianneuropathologyresilienceresistance To reference this document use: http://resolver.tudelft.nl/uuid:a12914c0-81b1-450c-a34a-acef2e1cff53 DOI https://doi.org/10.1002/alz.12899 ISSN 1552-5260 Source Alzheimer's & Dementia, 19 (7), 2831-2841 Part of collection Institutional Repository Document type journal article Rights © 2022 M. Zhang, Andrea B. Ganz, Susan Rohde, Annemieke J.M. Rozemuller, Netherlands Brain Bank, M.J.T. Reinders, Philip Scheltens, M. Hulsman, Jeroen J.M. Hoozemans, H. Holstege Files PDF Alzheimer_s_Dementia_2022 ... es_and.pdf 2.1 MB Close viewer /islandora/object/uuid:a12914c0-81b1-450c-a34a-acef2e1cff53/datastream/OBJ/view