Title
Building blocks for a European Organ-on-Chip roadmap
Author
Mastrangeli, Massimo (TU Delft Electronic Components, Technology and Materials) 
Millet, Sylvie (CEA Grenoble)
Mummery, Christine (Leiden University Medical Center)
Loskill, Peter (Fraunhofer IGB)
Braeken, Dries (IMEC)
Eberle, Wolfgang (IMEC)
Cipriano, Madalena (Fraunhofer IGB)
Fernandez, Luis (University of Zaragoza)
Graef, M.W.M. (TU Delft EEMCS Relations & Valorisation)
Gidrol, Xavier (CEA Grenoble)
Picollet-D'Hahan, Nathalie (CEA Grenoble)
van Meer, Berend (Leiden University Medical Center)
Ochoa, Ignacio (University of Zaragoza)
Schutte, Mieke (hDMT)
van den Eijnden-van Raaij, Janny (hDMT)
Date
2019-07-19
Abstract
This paper summarizes the outcome of the Organ-on-Chip (OoC) ORCHID Strategy workshop (Leiden, the Netherlands, 17 January 2019) intended to establish a European OoC roadmap through expert discussions, conclusions and recommendations. The workshop identified six specific building blocks for the OoC roadmap: (1) application, (2) specification, (3) qualification, (4) standardization, (5) production and upscaling, and (6) adoption. Complementary aspects relating to ethics and communication were also addressed. Priorities, methods and targets for the roadmap were proposed for each building block. General consensus was reached on the potential contribution of the newly founded European Organ-on-Chip Society (EUROoCS), which could facilitate deployment of each block. EUROoCS would ideally initiate and catalyze dialogue between OoC developers, end users and regulators. The dialogue should address qualification, open technology platforms, standardization and implementation of OoC technology, as well as ethical aspects of human tissue mimics, training the next generation of OoC researchers, dissemination and communication.
Subject
organ-on-chip
microphysiological systems
roadmap
qualification
adoption
Stem cells
organoids
open technology platform
To reference this document use:
http://resolver.tudelft.nl/uuid:abd47cd0-7449-4889-a22f-4c57b21a77b7
DOI
https://doi.org/10.14573/altex.1905221
ISSN
1868-596X
Source
ALTEX - Alternatives to Animal Experimentation, 36 (3), 481-492
Bibliographical note
green
Part of collection
Institutional Repository
Document type
journal article
Rights
© 2019 Massimo Mastrangeli, Sylvie Millet, Christine Mummery, Peter Loskill, Dries Braeken, Wolfgang Eberle, Madalena Cipriano, Luis Fernandez, M.W.M. Graef, Xavier Gidrol, Nathalie Picollet-D'Hahan, Berend van Meer, Ignacio Ochoa, Mieke Schutte, Janny van den Eijnden-van Raaij