Title
Microelectromechanical Organs-on-Chip
Author
Mastrangeli, Massimo (TU Delft Electronic Components, Technology and Materials) 
Aydogmus, H. (TU Delft Electronic Components, Technology and Materials)
Dostanic, M. (TU Delft Electronic Components, Technology and Materials)
Motreuil-Ragot, P.A. (TU Delft Electronic Components, Technology and Materials)
Revyn, N. (TU Delft Electronic Components, Technology and Materials)
de Wagenaar, B. (TU Delft Electronic Components, Technology and Materials)
Dekker, R. (TU Delft Electronic Components, Technology and Materials)
Sarro, Pasqualina M (TU Delft Electronic Components, Technology and Materials)
Date
2021
Abstract
Stemming from the convergence of tissue engineering and microfluidics, organ-on-chip (OoC) technology can reproduce in vivo-like dynamic microphysiological environments for tissues in vitro. The possibility afforded by OoC devices of realistic recapitulation of tissue and organ (patho)physiology may hold the key to bridge the current translational gap in drug development, and possibly foster personalized medicine. Here we underline the biotechnological convergence at the root of OoC technology, and outline research tracks under development in our group at TU Delft along two main directions: fabrication of innovative microelectromechanical OoC devices, integrating stimulation and sensing of tissue activity, and their embedding within advanced platforms for pre-clinical research. We conclude with remarks on the role of open technology platforms for the broader establishment of OoC technology in pre-clinical research and drug development.
Subject
Actuators
microelectrode arrays
microfabrication
open technology platforms
organ-on-chip
sensors
tissues
To reference this document use:
http://resolver.tudelft.nl/uuid:ad8f1e80-d7d7-4d8e-8dfb-d7ed1129d9b1
DOI
https://doi.org/10.1109/Transducers50396.2021.9495646
Publisher
IEEE
Embargo date
2022-02-06
ISBN
978-1-6654-4845-1
Source
21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
Event
2021 21st International Conference on Solid-State Sensors, Actuators and Microsystems (Transducers), 2021-06-20 → 2021-06-24, Virtual at Orlando, United States
Series
21st International Conference on Solid-State Sensors, Actuators and Microsystems, TRANSDUCERS 2021
Bibliographical note
Green Open Access added to TU Delft Institutional Repository ‘You share, we take care!’ – Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.
Part of collection
Institutional Repository
Document type
conference paper
Rights
© 2021 Massimo Mastrangeli, H. Aydogmus, M. Dostanic, P.A. Motreuil-Ragot, N. Revyn, B. de Wagenaar, R. Dekker, Pasqualina M Sarro