Print Email Facebook Twitter Hyaluronan biopolymers release water upon pH-induced gelation Title Hyaluronan biopolymers release water upon pH-induced gelation Author van Dam, Eliane P. (AMOLF) Giubertoni, Giulia (AMOLF) Burla, Federica (AMOLF) Koenderink, G.H. (TU Delft BN/Gijsje Koenderink Lab; Kavli institute of nanoscience Delft; AMOLF) Bakker, Huib J. (AMOLF) Date 2020 Abstract We study the relation between the macroscopic viscoelastic properties of aqueous hyaluronan polymer solutions and the molecular-scale dynamics of water using rheology measurements, differential dynamic microscopy, and polarization-resolved infrared pump-probe spectroscopy. We observe that the addition of hyaluronan to water leads to a slowing down of the reorientation of a fraction of the water molecules. Near pH 2.4, the viscosity of the hyaluronan solution reaches a maximum, while the number of slowed down water molecules reaches a minimum. This implies that the water molecules become on average more mobile when the solution becomes more viscous. This observation indicates that the increase in viscosity involves the expulsion of hydration water from the surfaces of the hyaluronan polymers, and a bundling of the hyaluronan polymer chains. To reference this document use: http://resolver.tudelft.nl/uuid:e72e5530-b8f8-4f40-8f37-c680d6589af6 DOI https://doi.org/10.1039/d0cp00215a Embargo date 2021-04-02 ISSN 1463-9076 Source Physical chemistry chemical physics (PCCP), 22 (16), 8667-8671 Bibliographical note Accepted Author Manuscript Part of collection Institutional Repository Document type journal article Rights © 2020 Eliane P. van Dam, Giulia Giubertoni, Federica Burla, G.H. Koenderink, Huib J. Bakker Files PDF Eliane_Hyaluronan_MainTex ... _Final.pdf 920.71 KB Close viewer /islandora/object/uuid:e72e5530-b8f8-4f40-8f37-c680d6589af6/datastream/OBJ/view