Print Email Facebook Twitter Selective Oxyfunctionalisation Reactions Driven by Sulfite Oxidase-Catalysed In Situ Generation of H2O2 Title Selective Oxyfunctionalisation Reactions Driven by Sulfite Oxidase-Catalysed In Situ Generation of H2O2 Author van Schie, M.M.C.H. (TU Delft BT/Biocatalysis) Kaczmarek, Alexander T. (University of Cologne) Tieves, F. (TU Delft BT/Biocatalysis) Gomez de Santos, Patricia (Institute of Catalysis, CSIC, Madrid) Paul, C.E. (TU Delft BT/Biocatalysis) Arends, I.W.C.E. (Universiteit Utrecht) Alcalde, Miguel (Institute of Catalysis, CSIC, Madrid) Schwarz, Günter (University of Cologne) Hollmann, F. (TU Delft BT/Biocatalysis) Date 2020 Abstract H2O2 can be accepted by several peroxygenases as a clean oxidant, able to supply both the necessary electrons and oxygen atom at the same time. The biocatalysts, in turn, are able to catalyse an array of interesting oxygen insertion reactions at enantio- and regio-selectivities hard to attain with classical chemical methods. The sensitivity of most peroxygenases towards H2O2, however, requires this oxidant to be generated in situ. Here, we suggest the application of (modified) sulfite oxidases to couple the oxidation of sulfites to the reduction of oxygen. This enables us to use calcium sulfite, an industrial waste product from scrubbing flue gases, as an electron donor to reduce oxygen. This will supply the required peroxide in a controlled manner and enables us to perform these challenging reactions at the expense of simple salts. Subject BiocatalysisHydrogen peroxideOxyfunctionalisationPeroxygenaseSulfite oxidase To reference this document use: http://resolver.tudelft.nl/uuid:ea07a76c-a60f-4e91-a979-8f02c7d20b17 DOI https://doi.org/10.1002/cctc.201902297 ISSN 1867-3880 Source ChemCatChem, 12 (12), 3186-3189 Part of collection Institutional Repository Document type journal article Rights © 2020 M.M.C.H. van Schie, Alexander T. Kaczmarek, F. Tieves, Patricia Gomez de Santos, C.E. Paul, I.W.C.E. Arends, Miguel Alcalde, Günter Schwarz, F. Hollmann Files PDF Schie_et_al_2020_ChemCatChem.pdf 1.06 MB Close viewer /islandora/object/uuid:ea07a76c-a60f-4e91-a979-8f02c7d20b17/datastream/OBJ/view