Bioengineered skin intended for skin disease modeling

Sarkiri, Maria; Fox, Stephan C.; Fratila-Apachitei, E.L.; Zadpoor, A.A.

doi:10.3390/ijms20061407

Bioengineered skin intended for skin disease modeling

Title

Bioengineered skin intended for skin disease modeling

Author

Sarkiri, Maria (Student TU Delft)
Fox, Stephan C. (ETH Zürich)
Fratila-Apachitei, E.L. (TU Delft Biomaterials & Tissue Biomechanics)
Zadpoor, A.A. (TU Delft Biomaterials & Tissue Biomechanics)

Date

2019

Abstract

Clinical use of bioengineered skin in reconstructive surgery has been established for more than 30 years. The limitations and ethical considerations regarding the use of animal models have expanded the application of bioengineered skin in the areas of disease modeling and drug screening. These skin models should represent the anatomical and physiological traits of native skin for the efficient replication of normal and pathological skin conditions. In addition, reliability of such models is essential for the conduction of faithful, rapid, and large-scale studies. Therefore, research efforts are focused on automated fabrication methods to replace the traditional manual approaches. This report presents an overview of the skin models applicable to skin disease modeling along with their fabrication methods, and discusses the potential of the currently available options to conform and satisfy the demands for disease modeling and drug screening.

Subject

bioengineered skin
biofabrication
skin disease modeling
standardization

To reference this document use:

http://resolver.tudelft.nl/uuid:20d0981d-d9e4-493b-870a-cb5f638366c7

DOI

https://doi.org/10.3390/ijms20061407

ISSN

1422-0067

Source

International Journal of Molecular Sciences (Online), 20 (6)

Part of collection

Institutional Repository