Print Email Facebook Twitter Homeostasis in intestinal organoids at the single cell level Title Homeostasis in intestinal organoids at the single cell level Author Kok, R.N.U. (TU Delft BN/Sander Tans Lab) Contributor Tans, S.J. (promotor) Ten Wolde, Pieter Rein (copromotor) Degree granting institution Delft University of Technology Date 2024-04-10 Abstract How does the small intestine maintain itself? What mechanism does it use to achievehomeostasis, and how optimal is this mechanism? We approached these questionsmainly using cell tracking in organoids, for which we developed new cell trackers.We found that the intestinal crypt uses a surprisingly simple and effective strategy.Finally, we showed that cell segmentation and tracking is possible in organoids without fluorescent markers. Subject organoidssmall intestinehomeostasiscell tracking To reference this document use: https://doi.org/10.4233/uuid:239cbb59-90d6-49b9-9dc5-ea6addb3d6e1 Part of collection Institutional Repository Document type doctoral thesis Rights © 2024 R.N.U. Kok Files PDF proefschrift-met-omslag.pdf 48.54 MB Close viewer /islandora/object/uuid:239cbb59-90d6-49b9-9dc5-ea6addb3d6e1/datastream/OBJ/view