Print Email Facebook Twitter Mn(III) porphyrins as potential MRI contrast agents for diagnosis and MRI-guided therapy Title Mn(III) porphyrins as potential MRI contrast agents for diagnosis and MRI-guided therapy Author Geraldes, Carlos F.G.C. (Universidade de Coimbra) Castro, M. Margarida C.A. (Universidade de Coimbra) Peters, J.A. (TU Delft BT/Biocatalysis) Date 2021 Abstract Mn(III) porphyrins have great potential as Gd-free MRI contrast agents because both the cation and the ligand have interesting properties. The redox properties of the Mn(III)-ion can be exploited for the preparation of reactive oxygen species for therapy. Moreover, the porphyrin ligand allows these complexes to have a high affinity for tumor tissues. The inherent properties of the porphyrin ligands make these systems attractive for photothermal, photodynamic, and sonodynamic therapies. Therefore, these systems are attractive for the development of theranostics for MRI-guided therapy. For the magnetic field strengths at which most clinical MRI machines operate at present (0.5–1.5 T), the longitudinal relativity of low-molecular-weight complexes is even higher than that of the classical Gd-based contrast agents. This review gives an overview of the developments in the field of Mn(III) porphyrin contrast agents during the last 30 years. Subject ChemotherapyPhotodynamic therapyPhotothermal therapyRelaxivityTheranostics To reference this document use: http://resolver.tudelft.nl/uuid:9b3b5848-33da-4238-90c8-7266cf41ec4e DOI https://doi.org/10.1016/j.ccr.2021.214069 Embargo date 2023-06-18 ISSN 0010-8545 Source Coordination Chemistry Reviews, 445 Bibliographical note Accepted Author Manuscript Part of collection Institutional Repository Document type review Rights © 2021 Carlos F.G.C. Geraldes, M. Margarida C.A. Castro, J.A. Peters Files PDF Mn_porphyrins_manuscript1.pdf 2.94 MB Close viewer /islandora/object/uuid:9b3b5848-33da-4238-90c8-7266cf41ec4e/datastream/OBJ/view