Print Email Facebook Twitter Functionalized Hydrogels for Articular Cartilage Tissue Engineering Title Functionalized Hydrogels for Articular Cartilage Tissue Engineering Author Zhou, Liangbin (Chinese University of Hong Kong) Guo, Peng (Chinese University of Hong Kong; AO Research Institute Davos, Davos) D'Este, Matteo (AO Research Institute Davos, Davos) Tong, Wenxue (Chinese University of Hong Kong) Xu, Jiankun (Chinese University of Hong Kong) Yao, Hao (Chinese University of Hong Kong) Stoddart, Martin J. (AO Research Institute Davos, Davos) van Osch, G.J.V.M. (TU Delft Biomaterials & Tissue Biomechanics; Erasmus MC) Ho, Kevin Ki Wai (Chinese University of Hong Kong) Li, Zhen (AO Research Institute Davos, Davos) Qin, Ling (Chinese Academy of Sciences; Chinese University of Hong Kong) Date 2022 Abstract Articular cartilage (AC) is an avascular and flexible connective tissue located on the bone surface in the diarthrodial joints. AC defects are common in the knees of young and physically active individuals. Because of the lack of suitable tissue-engineered artificial matrices, current therapies for AC defects, especially full-thickness AC defects and osteochondral interfaces, fail to replace or regenerate damaged cartilage adequately. With rapid research and development advancements in AC tissue engineering (ACTE), functionalized hydrogels have emerged as promising cartilage matrix substitutes because of their favorable biomechanical properties, water content, swelling ability, cytocompatibility, biodegradability, and lubricating behaviors. They can be rationally designed and conveniently tuned to simulate the extracellular matrix of cartilage. This article briefly introduces the composition, structure, and function of AC and its defects, followed by a comprehensive review of the exquisite (bio)design and (bio)fabrication of functionalized hydrogels for AC repair. Finally, we summarize the challenges encountered in functionalized hydrogel-based strategies for ACTE both in vivo and in vitro and the future directions for clinical translation. Subject Articular cartilageCartilage repairCartilage tissue engineeringClinical translationFunctionalized hydrogels To reference this document use: http://resolver.tudelft.nl/uuid:b744923a-1aa8-4826-9e88-220324010e0a DOI https://doi.org/10.1016/j.eng.2022.03.008 ISSN 2095-8099 Source Engineering, 13, 71-90 Part of collection Institutional Repository Document type review Rights © 2022 Liangbin Zhou, Peng Guo, Matteo D'Este, Wenxue Tong, Jiankun Xu, Hao Yao, Martin J. Stoddart, G.J.V.M. van Osch, Kevin Ki Wai Ho, Zhen Li, Ling Qin Files PDF 1_s2.0_S209580992200203X_main.pdf 7.26 MB Close viewer /islandora/object/uuid:b744923a-1aa8-4826-9e88-220324010e0a/datastream/OBJ/view