Print Email Facebook Twitter Challenges and Strategies for Optimizing Corrosion and Biodegradation Stability of Biomedical Micro- and Nanoswimmers Title Challenges and Strategies for Optimizing Corrosion and Biodegradation Stability of Biomedical Micro- and Nanoswimmers: A Review Author Rahimi, E. (TU Delft Materials Science and Engineering; Università degli Studi di Udine) Sanchis-Gual, Roger (ETH Zürich) Chen, Xiangzhong (ETH Zürich) Imani, Amin (University of British Columbia) Gonzalez Garcia, Y. (TU Delft Team Yaiza Gonzalez Garcia) Asselin, Edouard (University of British Columbia) Mol, J.M.C. (TU Delft Team Arjan Mol) Fedrizzi, Lorenzo (Università degli Studi di Udine) Pané, Salvador (ETH Zürich) Lekka, Maria (IK4-CIDETEC Research Centre) Department Materials Science and Engineering Date 2023 Abstract The last two decades have witnessed the emergence of micro- and nanoswimmers (MNSs). Researchers have invested significant efforts in engineering motile micro- and nanodevices to address current limitations in minimally invasive medicine. MNSs can move through complex fluid media by using chemical fuels or external energy sources such as magnetic fields, ultrasound, or light. Despite significant advancements in their locomotion and functionalities, the gradual deterioration of MNSs in human physiological media is often overlooked. Corrosion and biodegradation caused by chemical reactions with surrounding medium and the activity of biological agents can significantly affect their chemical stability and functional properties during their lifetime performance. It is therefore essential to understand the degradation mechanisms and factors that influence them to design ideal biomedical MNSs that are affordable, highly efficient, and sufficiently resistant to degradation (at least during their service time). This review summarizes recent studies that delve into the physicochemical characteristics and complex environmental factors affecting the corrosion and biodegradation of MNSs, with a focus on metal-based devices. Additionally, different strategies are discussed to enhance and/or optimize their stability. Conversely, controlled degradation of non-toxic MNSs can be highly advantageous for numerous biomedical applications, allowing for less invasive, safer, and more efficient treatments. Subject biodegradationbiomedicinecorrosionsmall-scale swimmers To reference this document use: http://resolver.tudelft.nl/uuid:cd97bff5-88c6-40de-b670-b270e5fdd569 DOI https://doi.org/10.1002/adfm.202210345 ISSN 1616-301X Source Advanced Functional Materials, 33 (44) Part of collection Institutional Repository Document type review Rights © 2023 E. Rahimi, Roger Sanchis-Gual, Xiangzhong Chen, Amin Imani, Y. Gonzalez Garcia, Edouard Asselin, J.M.C. Mol, Lorenzo Fedrizzi, Salvador Pané, Maria Lekka Files PDF Adv_Funct_Materials_2023_ ... ity_of.pdf 4.25 MB Close viewer /islandora/object/uuid:cd97bff5-88c6-40de-b670-b270e5fdd569/datastream/OBJ/view