Rapid Prototyping of Organ-on-a-Chip Devices Using Maskless Photolithography

Organ-on-a-chip (OoC) and microfluidic devices are conventionally produced using microfabrication procedures that require cleanrooms, silicon wafers, and photomasks. The prototyping stage often requires multiple iterations of design steps. A simplified prototyping process could therefore offer major advantages. Here, we describe a rapid and...

A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties

We present a wafer-scale fabricated, PDMS-based platform for culturing miniaturized engineered heart tissues (EHTs) which allows highly accurate measurements of the contractile properties of these tissues. The design of the platform is an anisometrically downscaled version of the Heart-Dyno system, consisting of two elastic micropillars inside...

Miniaturized engineered heart tissues from human induced pluripotent cell-derived co-culture

Miniaturized engineered heart tissues from HiPSC-derived co-culture

Enabling actuation and sensing in organs-on-chip using electroactive polymers

Organ-on-chip (OoC) devices are in rising demand for high-throughput and low-cost development and toxico-logical screening of chemicals and pharmaceuticals, as they accurately mimic in vitro physiological conditions as in the human body. In particular, OoCs are urgently needed for screening cardiovascular drug toxicity. Physiological relevance...

Enabling actuation and sensing in organs-on-chip using electroactive polymers

•Actuation has been succesfully performed for 2h30 with no side effects nor<br/>delimination of the human tissue <br/>•0.1 % strain has been achieved during the actutaion mode, close to the<br/>strain experienced in vivo by vSMCs <br/>•0.72 V/mm sensitivity has been shown on the sensing mode <br/>•Batch fabrication and downscaling will be...

Image beam from a wire laser

We demonstrate the formation of a narrow beam from a long (L??) laser with subwavelength transverse dimensions (wire laser) as an image of the subwavelength laser waveguide formed by a spherical lens. The beam is linearly diverging with the angle determined by the ratio of the wavelength to the lens radius, while the minimum beam spot size is...

Beam patterns of terahertz quantum cascade lasers with subwavelength cavity dimensions

The need to reach single-mode lasing and minimize at the same time the electrical dissipation of cryogenically operated terahertz quantum cascade lasers may result in small and subwavelength cavity dimensions. To assess the influence of such dimensions on the shape of the laser emission, we have measured the beam pattern of two metal-metal...

Antenna model for wire lasers

Stimulated terahertz emission from group-V donors in silicon under intracenter photoexcitation

Frequency-tunable radiation from the free electron laser FELIX was used to excite neutral phosphorus and bismuth donors embedded in bulk monocrystalline silicon. Lasing at terahertz frequencies has been observed at liquid helium temperature while resonant pumping of odd parity impurity states. The threshold was about two orders of magnitude...

Transverse mode structure and output stability of the p-Ge terahertz laser