Spatial relationships in the urothelial and head and neck tumor microenvironment predict response to combination immune checkpoint inhibitors

Immune checkpoint inhibitors (ICI) can achieve remarkable responses in urothelial cancer (UC), which may depend on tumor microenvironment (TME) characteristics. However, the relationship between the TME, usually characterized by immune cell density, and response to ICI is unclear. Here, we quantify the TME immune cell densities and spatial...

Corrigendum to “Assessment of Predictive Genomic Biomarkers for Response to Cisplatin-based Neoadjuvant Chemotherapy in Bladder Cancer” [Eur Urol 2023;83:313–17] (European Urology (2023) 83(4) (313–317), (S0302283822025386), (10.1016/j.eururo.2022.07.023))

The authors regret that the following statement regarding author contributions was missed: Kristan van der Vos is currently a Scientific Editor for Cell Reports Medicine, which is published by Elsevier. Dr van der Vos was not involved in the peer-review process or editorial discussions about this manuscript. The authors would like to...

Assessment of Predictive Genomic Biomarkers for Response to Cisplatin-based Neoadjuvant Chemotherapy in Bladder Cancer

Cisplatin-based neoadjuvant chemotherapy (NAC) followed by radical cystectomy is recommended for patients with muscle-invasive bladder cancer (MIBC). It has been shown that somatic deleterious mutations in ERCC2, gain-of-function mutations in ERBB2, and alterations in ATM, RB1, and FANCC are correlated with pathological response to NAC in...

Effect of chloride salts on sulfoaluminate cement hydration

The effect of including 5 % chloride salts (NaCl and CaCl2) on calcium sulfoaluminate cement hydration was studied. The rate of heat release, setting times and mechanical strength were determined in 2 d, 28 d and 90 d cement pastes. The hydration products formed at those ages were identified with XRD and SEM. Hydration reactions were hastened...

The Tumor Immune Landscape and Architecture of Tertiary Lymphoid Structures in Urothelial Cancer

Candidate immune biomarkers have been proposed for predicting response to immunotherapy in urothelial cancer (UC). Yet, these biomarkers are imperfect and lack predictive power. A comprehensive overview of the tumor immune contexture, including Tertiary Lymphoid structures (TLS), is needed to better understand the immunotherapy response in UC...

On the Coupling of Orbit and Attitude Determination of Satellite Formations from Atmospheric Drag: Observability and Estimation Performance

Spacecraft orbit and attitude dynamics have been classically seen as two separated<br/>subjects, since the effect of attitude in orbit dynamics was deemed too small to be<br/>considered, or simply, modeled as noise in the estimation process for most satellites.<br/>In the eighties, a study by [1] showed that for a very large spacecraft,...

Impact of dynamic coupling between relative orbit and attitude on the estimation of relative dynamics of spacecraft

In this work the extent to which orbit and attitude sensors may cross-support each other in a joint processing to reduce estimation errors of the relative orbital and attitude dynamics is investigated. In order to do this, an engineering dynamic model taking into account the coupling effects between orbit and attitude dynamics is exploited...

Effects of visual fidelity on curve negotiation, gaze behaviour and simulator discomfort

Technological developments have led to increased visual fidelity of driving simulators. However, simplified visuals have potential advantages, such as improved experimental control, reduced simulator discomfort and increased generalisability of results. In this driving simulator study, we evaluated the effects of visual fidelity on driving...

Flexible framework for the development of versatile MAV systems for multi-disciplinary applications

MAV (Micro Aerial Vehicle) systems have proven useful in multiple applications (e.g. aerial photogrammetry, aerial inspections,...). For each application different sensors and even different airframes are often needed. Having a flexible UAS (Unmanned Aircraft System) devices (specifically an autopilot, a payload manager and a ground control...