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Beyranvand Nejad, A. (author)Recent trends show a steady increase towards concurrently executing more and more applications on a single embedded system. Multi-Processor System-on-Chip (MPSoC) architectures are proposed to allow complex design of embedded systems. This is achieved by integrating as many processing resources as possible on a single chip and therefore enabling...doctoral thesis 2014
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Dullemond, K. (author)More and more, software engineering projects are no longer carried out in a single office building, but instead in multiple dislocated office buildings or even from home. When the development process is distributed between several geographically dispersed locations this is known as Global Software Engineering or GSE. The team members working on...doctoral thesis 2014
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Huser, C.A. (author), Gilroy, K.L. (author), De Ridder, J. (author), Kilbey, A. (author), Borland, G. (author), Mackay, N. (author), Jenkins, A. (author), Bell, M. (author), Herzyk, P. (author), Van der Weyden, L. (author)Retroviral insertional mutagenesis (RIM) is a powerful tool for cancer genomics that was combined in this study with deep sequencing (RIM/DS) to facilitate a comprehensive analysis of lymphoma progression. Transgenic mice expressing two potent collaborating oncogenes in the germ line (CD2-MYC, -Runx2) develop rapid onset tumours that can be...journal article 2014
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De Ronde, J.J. (author), Bonder, M.J. (author), Lips, E.H. (author), Rodenhuis, S. (author), Wessels, L.F.A. (author)Introduction: Despite continuous efforts, not a single predictor of breast cancer chemotherapy resistance has made it into the clinic yet. However, it has become clear in recent years that breast cancer is a collection of molecularly distinct diseases. With ever increasing amounts of breast cancer data becoming available, we set out to study if...journal article 2014
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- Steenhuisen, J.R. (author) doctoral thesis 2013
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Klijn, C. (author), Koudijs, M.J. (author), Kool, J. (author), Ten Hoeve, J. (author), Boer, M. (author), De Moes, J. (author), Akhtar, W. (author), Van Miltenburg, M. (author), Vendel-Zwaagstra, A. (author), Reinders, M.J.T. (author), Adams, D.J. (author), Van Lohuizen, M. (author), Hilkens, J. (author), Wessels, L.F.A. (author), Jonkers, J. (author)Cancer develops through a multistep process in which normal cells progress to malignant tumors via the evolution of their genomes as a result of the acquisition of mutations in cancer driver genes. The number, identity and mode of action of cancer driver genes, and how they contribute to tumor evolution is largely unknown. This study deployed...journal article 2013
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- Scharpff, J. (author), Spaan, T.J. (author), Volker, L. (author), De Weerdt, M. (author) conference paper 2013
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Grimes, M.L. (author), Lee, W.J. (author), Van der Maaten, L. (author), Shannon, P. (author)The interpretation of biological data sets is essential for generating hypotheses that guide research, yet modern methods of global analysis challenge our ability to discern meaningful patterns and then convey results in a way that can be easily appreciated. Proteomic data is especially challenging because mass spectrometry detectors often miss...journal article 2013
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Khmelinskii, A. (author), Groen, H.C. (author), De Jong, M. (author), Lelieveldt, B.P.F. (author)Whole-body SPECT small animal imaging is used to study cancer, and plays an important role in the development of new drugs. Comparing and exploring whole-body datasets can be a difficult and time-consuming task due to the inherent heterogeneity of the data (high volume/throughput, multi-modality, postural and positioning variability). The goal...journal article 2012
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Van den Berg, B.A. (author), Reinders, M.J.T. (author), Hulsman, M. (author), Wu, L. (author), Pel, H.J. (author), Roubos, J.A. (author), De Ridder, D. (author)Protein sequence features are explored in relation to the production of over-expressed extracellular proteins by fungi. Knowledge on features influencing protein production and secretion could be employed to improve enzyme production levels in industrial bioprocesses via protein engineering. A large set, over 600 homologous and nearly 2,000...journal article 2012
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Gielis, J. (author), Caratelli, D. (author), Fougerolle, Y. (author), Ricci, P.E. (author), Tavkelidze, I. (author), Gerats, T. (author)Gielis curves and surfaces can describe a wide range of natural shapes and they have been used in various studies in biology and physics as descriptive tool. This has stimulated the generalization of widely used computational methods. Here we show that proper normalization of the Levenberg-Marquardt algorithm allows for efficient and robust...journal article 2012
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Alves, H. (author), Van Ginkel, J. (author), Groen, N. (author), Hulsman, N. (author), Mentink, A. (author), Reinders, M.J.T. (author), Van Blitterswijk, C. (author), De Boer, J. (author)Human aging is associated with loss of function and regenerative capacity. Human bone marrow derived mesenchymal stromal cells (hMSCs) are involved in tissue regeneration, evidenced by their capacity to differentiate into several lineages and therefore are considered the golden standard for cell-based regeneration therapy. Tissue maintenance and...journal article 2012
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Loni, B. (author)The task of question classification (QC) is to predict the entity type of a question which is written in natural language. This is done by classifying the question to a category from a set of predefined categories. Question classification is an important component of question answering systems and it attracted a notable amount of research since...journal article 2011
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Van den Bogert, H. (author), Haasnoot, E. (author), Van Kaam, N. (author), Simons, G. (author)Many problems do not have a direct solution in the form of a known algorithm or program to solve such a problem. These problems include, for example, the designing of electrical circuits and producing robots capable of locomotion. These are all part of a greater problem: the problem of synthesis. How can you make a computer design circuits and...journal article 2011
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Strydis, C. (author)HEALTHCARE in the 21st century is changing rapidly. In advanced countries, in particular, healthcare is moving from a public to a more personalized nature. However, the costs of healthcare worldwide are increasing every year. Better use of technology can and should be used to get control of these costs. At the same time, implants have clearly...doctoral thesis 2011
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Nijkamp, J.F. (author), Winterbach, W. (author), Van den Broek, M. (author), Daran, J.M. (author), Reinders, M.J.T. (author), De Ridder, D. (author)De novo assembly of a eukaryotic genome with next-generation sequencing data is still a challenging task. Over the past few years several assemblers have been developed, often suitable for one specific type of sequencing data. The number of known genomes is expanding rapidly, therefore it becomes possible to use multiple reference genomes for...journal article 2010
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Wilmer, D.W.H. (author), De Ridder, G.R. (author), Kol, A.A. (author), Harkes, D.C. (author)This bachelor report describes the creation of a fun and informative robot game for the Science Centre Delft. The project entails simulating the classic Pacman computer game using real robots. One robot, Pacman, is controlled by a player and has to fulfil certain assignments. Simultaneously the other robots, monsters, try to catch Pacman. A...report 2010
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Blaas, J. (author)This thesis investigates methods for the visualization of multi-field medical data. In the medical field, data complexity has been growing consistently over the past years. Not only the size of the data grows, but also the need to visualize beyond traditional boundaries. We present a number of novel facets that encompass a general approach to...doctoral thesis 2010
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Gonzalez, A. (author), Piel, E. (author), Gross, H.G. (author)Version: Accepted as short paper at QSIC 2009. Runtime testing is emerging as the solution for the integration and assessment of highly dynamic, high availability software systems where traditional development-time integration testing is too costly, or cannot be performed. However, in many situations, an extra cost will have to be invested in...report 2009
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Oosterman, J.E.G. (author), Ravenhorst, R. (author), Witteveen, C. (author), Van Leeuwen, P. (author)At airports, the turnaround process of aircraft is crucial for a timely and efficient handling of air traffic. During this process, a number of services need to be provided during the time the aircraft is at the gate: e.g., de-boarding, cleaning, catering, fuelling, and boarding. These services are provided by different service providers (agents...conference paper 2008
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