Composable Virtual Platforms for Mixed-Criticality Embedded Systems

Recent trends show a steady increase towards concurrently executing more and more applications on a single embedded system. Multi-Processor System-on-Chip (MPSoC) architectures are proposed to allow complex design of embedded systems. This is achieved by integrating as many processing resources as possible on a single chip and therefore enabling...

Insertional Mutagenesis and Deep Profiling Reveals Gene Hierarchies and a Myc/p53-Dependent Bottleneck in Lymphomagenesis

Retroviral insertional mutagenesis (RIM) is a powerful tool for cancer genomics that was combined in this study with deep sequencing (RIM/DS) to facilitate a comprehensive analysis of lymphoma progression. Transgenic mice expressing two potent collaborating oncogenes in the germ line (CD2-MYC, -Runx2) develop rapid onset tumours that can be...

Breast cancer subtype specific classifiers of response to neoadjuvant chemotherapy do not outperform classifiers trained on all subtypes

Introduction: Despite continuous efforts, not a single predictor of breast cancer chemotherapy resistance has made it into the clinic yet. However, it has become clear in recent years that breast cancer is a collection of molecularly distinct diseases. With ever increasing amounts of breast cancer data becoming available, we set out to study if...

Planning under uncertainty for coordinating infrastructural maintenance

Exploring Sequence Characteristics Related to High- Level Production of Secreted Proteins in Aspergillus niger

Protein sequence features are explored in relation to the production of over-expressed extracellular proteins by fungi. Knowledge on features influencing protein production and secretion could be employed to improve enzyme production levels in industrial bioprocesses via protein engineering. A large set, over 600 homologous and nearly 2,000...

RiTMO: A Method for Runtime Testability Measurement and Optimisation

Version: Accepted as short paper at QSIC 2009. Runtime testing is emerging as the solution for the integration and assessment of highly dynamic, high availability software systems where traditional development-time integration testing is too costly, or cannot be performed. However, in many situations, an extra cost will have to be invested in...