A fluoroscopy-based planning and guidance software tool for minimally invasive hip refixation by cement injection

Purpose In orthopaedics, minimally invasive injection of bone cement is an established technique. We present HipRFX, a software tool for planning and guiding a cement injection procedure for stabilizing a loosening hip prosthesis. HipRFX works by analysing a pre-operative CT and intraoperative C-arm fluoroscopic images. Methods HipRFX simulates...

Sequence-based learning algorithms for understanding and improving protein characteristics

The development of high-throughput measurement techniques resulted in rapidlyincreasing amounts of biological data, which made computational methodsessential for biological research. Hence, the field of bioinformatics emergedthat since plays an important role in storing, making accessible, integrating,and analysing different types of biological...

Insight into neutral and disease-associated human genetic variants through interpretable predictors

A variety of methods that predict human nonsynonymous single nucleotide polymorphisms (SNPs) to be neutral or disease-associated have been developed over the last decade. These methods are used for pinpointing disease-associated variants in the many variants obtained with next-generation sequencing technologies. The high performances of current...

SPiCE: A web-based tool for sequence-based protein classification and exploration

Background Amino acid sequences and features extracted from such sequences have been used to predict many protein properties, such as subcellular localization or solubility, using classifier algorithms. Although software tools are available for both feature extraction and classifier construction, their application is not straightforward,...