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van der Lee, S.J. (author), De Rojas, I. (author), Holstege, H. (author), Hulsman, M. (author), Reinders, M.J.T. (author), Tesi, N. (author), van Rooij, Jeroen (author), Zhao, Y. (author), Zhang, X. (author)Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage<br/>genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found...journal article 2022
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Holstege, H. (author), Hulsman, M.J. (author), Charbonnier, Camille (author), Grenier-Boley, Banjamin (author), Quenez, Olivier (author), Grozeva, Detelina (author), van Rooij, Jeroen G.J. (author), Reinders, M.J.T. (author), van der Lee, S.J. (author)Alzheimer’s disease (AD), the leading cause of dementia, has an estimated<br/>heritability of approximately 70%1. The genetic component of AD has been mainly assessed using genome-wide association studies, which do not capture the risk contributed by rare variants2. Here, we compared the gene-based burden of rare damaging variants in exome...journal article 2022
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Mol, Merel O. (author), van der Lee, S.J. (author), Hulsman, M. (author), Pijnenburg, Yolande A.L. (author), Scheltens, Phillip (author), Seelaar, Harro (author), van Swieten, John C. (author), Kaat, Laura Donker (author), Holstege, H. (author), van Rooij, Jeroen G.J. (author)Background: Many families with clinical early-onset Alzheimer’s disease (EOAD) remain genetically unexplained. A combination of genetic factors is not standardly investigated. In addition to monogenic causes, we evaluated the possible polygenic architecture in a large series of families, to assess if genetic testing of familial EOAD could be...journal article 2022
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Triebel, R. (author), Arras, K. (author), Alami, R. (author), Beyer, L. (author), Breuers, S. (author), Chatila, R. (author), Chetouani, M. (author), Cremers, D. (author), Evers, V. (author), Fiore, M. (author), Hung, H.S. (author), Islas Ram¿rez, O. (author), Joosse, M. (author), Khambhaita, H. (author), Kucner, T. (author), Leibe, B. (author), Lilienthal, A.J. (author), Linder, T. (author), Lohse, M. (author), Magnusson, M. (author), Okal, B. (author), Palmieri, L. (author), Rafi, U. (author), van Rooij, M. (author), Zhang, L. (author)We present an ample description of a socially compliant mobile robotic platform, which is developed in the EU-funded project SPENCER. The purpose of this robot is to assist, inform and guide passengers in large and busy airports. One particular aim is to bring travellers of connecting flights conveniently and efficiently from their arrival gate...conference paper 2015