- document
- Passtoors, W.M. (author), Van den Akker, E.B. (author), Deelen, J. (author), Maier, A.B. (author), Van der Breggen, R. (author), Jansen, R. (author), Trompet, S. (author), Van Heemst, D. (author), Derhovanessian, E. (author), Pawelec, G. (author), Van Ommen, G.J.B. (author), Slagboom, P.E. (author), Beekman, M. (author) journal article 2015
- document
-
Van den Akker, E.B. (author), Passtoors, W.M. (author), Jansen, R. (author), Van Zwet, E.W. (author), Goeman, J.J. (author), Hulsman, M. (author), Emilsson, V. (author), Perola, M. (author), Willemsen, G. (author), Penninx, B.W.J.H. (author), Heijmans, B.T. (author), Maier, A.B. (author), Boomsma, D.I. (author), Kok, J.N. (author), Slagboom, P.E. (author), Reinders, M.J.T. (author), Beekman, M. (author)The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approach for combining multiple...journal article 2013
- document
-
Passtoors, W.M. (author), Boer, J.M. (author), Goeman, J.G. (author), Van den Akker, E.B. (author), Deelen, J. (author), Zwaan, B.J. (author), Scarborough, A. (author), Van der Breggen, R. (author), Vossen, R.H.A.M. (author)The Leiden Longevity Study consists of families that express extended survival across generations, decreased morbidity in middle-age, and beneficial metabolic profiles. To identify which pathways drive this complex phenotype of familial longevity and healthy aging, we performed a genome-wide gene expression study within this cohort to screen for...journal article 2012