Iterative multiscale gradient computation for heterogeneous subsurface flow

We introduce a semi-analytical iterative multiscale derivative computation methodology that allows for error control and reduction to any desired accuracy, up to fine-scale precision. The model responses are computed by the multiscale forward simulation of flow in heterogeneous porous media. The derivative computation method is based on the...

Detecting Problematic Lookup Functions in Spreadsheets

Spreadsheets are used heavily in many business domains around the world. They are easy to use and as such enable end-user programmers to and build and maintain all sorts of reports and analyses. In addition to using spreadsheets for modeling and calculation, spreadsheets are often also used for creating reports and dashboards: combining data...

IL7R gene expression network associates with human healthy ageing

Enron versus EUSES: A comparison of two spreadsheet corpora

Spreadsheets are widely used within companies and often form the basis for business decisions. Numerous cases are known where incorrect information in spreadsheets lead to incorrect decisions. Such cases underline the relevance of research on the professional use of spreadsheets. Recently a new dataset became available for research, containing...

Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein–protein interaction modules as robust markers of human aging

The bodily decline that occurs with advancing age strongly impacts on the prospects for future health and life expectancy. Despite the profound role of age in disease etiology, knowledge about the molecular mechanisms driving the process of aging in humans is limited. Here, we used an integrative network-based approach for combining multiple...

Model-reduced gradient-based history matching

Gradient-based history matching algorithms can be used to adapt the uncertain parameters in a reservoir model using production data. They require, however, the implementation of an adjoint model to compute the gradients, which is usually an enormous programming effort. We propose a new approach to gradient-based history matching which is based...

Variational estimation of permeability and model errors from 3D and 4D seismic data using model-driven regularization

Comparison of the ensemble Kalman filter and a modified representer method for sensitivity to prior data

Ultra-Thin Deformable Silicon Substrates with Lateral Segmentation and Flexible Metal Interconnect

Our progress in developing technology modules for deformable single-crystalline-silicon electronics is presented in this contribution. Additional deformability/reliability is accomplished by modifications of the previously reported ultra-thin and flexible CIRCONFLEX technology (1). The flexibility is added in the last steps of the process flow...

An efficient gradient-based parameter estimation algorithm using representer expansions

Robust optimization of oil reservoir flooding

Interior point techniques in optimization: Complementarity, sensitivity and algorithms

Improving Production Schedules Without Scheduling

Manufacturing and knowledge-based systems in Singapore, Hong Kong and Korea

Report of a researh trip funded by the European Commission through the Esprit projects 809 and 2415. The trip was made from 19 March 1990 - 9 April 1990.

Investigations on nonlinear streamcipher systems: Construction and evaluation methods