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Bruin, S.C. (author), Klijn, C.N. (author), Liefers, G.J. (author), Braaf, L.M. (author), Joosse, S.A. (author), Van Beers, E.H. (author), Verwaal, V.J. (author), Morreau, H. (author), Wessels, L.F. (author), Van Velthuysen, M.L.F. (author), Tollenaar, R.A.E.M. (author), Van 't Veer, L.J. (author)
Background: Accurate staging of colorectal cancer (CRC) with clinicopathological parameters is important for predicting prognosis and guiding treatment but provides no information about organ site of metastases. Patterns of genomic aberrations in primary colorectal tumors may reveal a chromosomal signature for organ specific metastases. Methods:...
journal article 2010
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Holstege, H. (author), Van Beers, E. (author), Velds, A. (author), Liu, X. (author), Joosse, S.A. (author), Klarenbeek, S. (author), Schut, E. (author), Kerkhoven, R. (author), Klijn, C.N. (author), Wessels, L.F.A. (author), Nederlof, P.M. (author), Jonkers, J. (author)
Background: Genomic gains and losses are a result of genomic instability in many types of cancers. BRCA1- and BRCA2-mutated breast cancers are associated with increased amounts of chromosomal aberrations, presumably due their functions in genome repair. Some of these genomic aberrations may harbor genes whose absence or overexpression may give...
journal article 2010
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Lai, C. (author), Horlings, H.M. (author), Van De Vijver, M.J. (author), Van Beers, E.H. (author), Nederlof, P.M. (author), Wessels, L.F.A. (author), Reinders, M.J.T. (author)
journal article 2007