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Laczny, C.C. (author), Sternal, T. (author), Plugaru, V. (author), Gawron, P. (author), Atashpendar, A. (author), Margossian, H.H. (author), Coronado, S. (author), Van der Maaten, L.J.M. (author), Vlassis, N. (author), Wilmes, P. (author)Background: Metagenomics is limited in its ability to link distinct microbial populations to genetic potential due to a current lack of representative isolate genome sequences. Reference-independent approaches, which exploit for example inherent genomic signatures for the clustering of metagenomic fragments (binning), offer the prospect to...journal article 2015