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Meuleman, W. (author), Engwegen, J.Y.M.N. (author), Gast, M.C.W. (author), Wessels, L.F.A. (author), Reinders, M.J.T. (author)
journal article 2009
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Van Vliet, M.H. (author), Wessels, L.F.A. (author), Reinders, M.J.T. (author)
journal article 2009
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Knijnenburg, T.A. (author), Daran, J.M.G. (author), Van den Broek, M.A. (author), Daran-Lapujade, P.A.S. (author), De Winde, J.H. (author), Pronk, J.T. (author), Reinders, M.J.T. (author), Wessels, L.F.A. (author)
OA Fund TU delft Background: Microorganisms adapt their transcriptome by integrating multiple chemical and physical signals from their environment. Shake-flask cultivation does not allow precise manipulation of individual culture parameters and therefore precludes a quantitative analysis of the (combinatorial) influence of these parameters on...
journal article 2009
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Van Uitert, M. (author), Meuleman, W. (author), Wessels, L.F.A. (author)
Genomic datasets often consist of large, binary, sparse data matrices. In such a dataset, one is often interested in finding contiguous blocks that (mostly) contain ones. This is a biclustering problem, and while many algorithms have been proposed to deal with gene expression data, only two algorithms have been proposed that specifically deal...
journal article 2008
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Knijnenburg, T.A. (author), Wessels, L.F.A. (author), Reinders, M.J.T. (author)
Motivation: Cells receive a wide variety of environmental signals, which are often processed combinatorially to generate specific genetic responses. Changes in transcript levels, as observed across different environmental conditions, can, to a large extent, be attributed to changes in the activity of transcription factors (TFs). However, in...
journal article 2008
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Klijn, C.N. (author), Holstege, H. (author), De Ridder, J. (author), Liu, X. (author), Reinders, M. (author), Jonkers, J. (author), Wessels, L. (author)
Tumor formation is in part driven by DNA copy number alterations (CNAs), which can be measured using microarray-based Comparative Genomic Hybridization (aCGH). Multiexperiment analysis of aCGH data from tumors allows discovery of recurrent CNAs that are potentially causal to cancer development. Until now, multiexperiment aCGH data analysis has...
journal article 2008
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Meuleman, W. (author), Engwegen, J.Y.M.N. (author), Gast, M.C.W. (author), Beijnen, J.H. (author), Reinders, M.J.T. (author), Wessels, L.F.A. (author)
OA Fund TU Delft
journal article 2008
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Reyal, F. (author), Van Vliet, M.H. (author), Armstrong, N.J. (author), Horlings, H.M. (author), De Visser, K.E. (author), Kok, M. (author), Teschendorff, A.E. (author), Mook, S. (author), Van 't Veer, L. (author), Caldas, C. (author), Salmon, R.J. (author), Vijver, M.J. (author), Wessels, L.F.A. (author)
journal article 2008
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Van Vliet, M.H. (author), Reyal, F. (author), Horlings, H.M. (author), Van De Vijver, M.J. (author), Reinders, M.J.T. (author), Wessels, L.F.A. (author)
OA fund TU Delft
journal article 2008
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Van Vliet, M.H. (author), Klijn, C.N. (author), Wessels, L.F. (author), Reinders, M.J.T. (author)
Background. The availability of large collections of microarray datasets (compendia), or knowledge about grouping of genes into pathways (gene sets), is typically not exploited when training predictors of disease outcome. These can be useful since a compendium increases the number of samples, while gene sets reduce the size of the feature space....
journal article 2007
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De Ridder, J. (author), Kool, J. (author), Uren, A. (author), Bot, J. (author), Wessels, L. (author), Reinders, M. (author)
Motivation: Cancers are caused by an accumulation of multiple independent mutations that collectively deregulate cellular pathways, e.g. such as those regulating cell division and cell-death. The publicly available Retroviral Tagged Cancer Gene Database (RTCGD) contains the data of many insertional mutagenesis screens, in which the virally...
journal article 2007
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Knijnenburg, T.A. (author), De Winde, J.H. (author), Daran, J.M. (author), Daran-Lapujade, P. (author), Pronk, J.T. (author), Reinders, M.J.T. (author), Wessels, L.F.A. (author)
journal article 2007
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Lai, C. (author), Horlings, H.M. (author), Van De Vijver, M.J. (author), Van Beers, E.H. (author), Nederlof, P.M. (author), Wessels, L.F.A. (author), Reinders, M.J.T. (author)
journal article 2007
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Knijnenburg, T.A. (author), De Winde, J.H. (author), Daran, J.M. (author), Daran-Lapujade, P. (author), Pronk, J.T. (author), Reinders, M.J.T. (author), Wessels, L.F.A. (author)
journal article 2007
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De Ridder, J. (author), Uren, A. (author), Kool, J. (author), Reinders, M. (author), Wessels, L. (author)
Retroviral insertional mutagenesis screens, which identify genes involved in tumor development in mice, have yielded a substantial number of retroviral integration sites, and this number is expected to grow substantially due to the introduction of high-throughput screening techniques. The data of various retroviral insertional mutagenesis...
journal article 2006
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Lai, C. (author), Reinders, M.J. (author), Van 't Veer, L.J. (author), Wessels, L.F. (author)
journal article 2006
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Lai, C. (author), Reinders, M.J.T. (author), Van't Veer, L.J. (author), Wessels, L.F.A. (author)
journal article 2006
Searched for: faculty%3A%22Electrical%255C%252BEngineering%252C%255C%252BMathematics%255C%252Band%255C%252BComputer%255C%252BScience%22
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