Biocompatible optical physically unclonable function hydrogel microparticles for on-dose authentication

On-dose authentication (ODA) enhances security by incorporating customized molecular or micro-tags into each pill, preventing counterfeit products in genuine packages. ODA's security relies on tag non-replication and non-reverse engineering. Combining ODA with graphical Physical Unclonable Functions (PUF) promises maximum security. PUF uses...

“Mg” Bone: Ink extrusion-based additive manufacturing of Mg implants

The treatment of largy bone defect remains challenging in clinics. All the clinically available bone grafts have their own limitations and are not ideal for the treatment. Therefore, developing a new generation of suitable bone substitutes is urgently needed. In the recent years, porous magnesium (Mg) has been extensively studied for orthopedic...

Effectiveness of BMP-2 and PDGF-BB Adsorption onto a Collagen/Collagen-Magnesium-Hydroxyapatite Scaffold in Weight-Bearing and Non-Weight-Bearing Osteochondral Defect Bone Repair: In Vitro, Ex Vivo and In Vivo Evaluation

Despite promising clinical results in osteochondral defect repair, a recently developed bi-layered collagen/collagen-magnesium-hydroxyapatite scaffold has demonstrated less optimal subchondral bone repair. This study aimed to improve the bone repair potential of this scaffold by adsorbing bone morphogenetic protein 2 (BMP-2) and/or platelet...

Physiomimetic biocompatibility evaluation of directly printed degradable porous iron implants using various cell types

Additively manufactured (AM) degradable porous metallic biomaterials offer unique opportunities for satisfying the design requirements of an ideal bone substitute. Among the currently available biodegradable metals, iron has the highest elastic modulus, meaning that it would benefit the most from porous design. Given the successful...

A 3D Printed Mechanical Expander for Small Pupils

Technology platform for advanced neurostimulation implants: The “chip-in-tip” DBS probe

The progress in the field of neurostimulation is impressive, both from a technical as well as from a therapeutic point of view. Nowadays, the electrical stimulation of the nervous system can be used to induce or suppress muscle responses. Additionally, it can also influence hearing, vision, immune system response, pain perception, and even...

Lanthanide-doped NaYF₄ near-infrared-II nanothermometers for deep tissue temperature sensing

In this work, different lanthanides (Tm³⁺, Er³⁺; Yb³⁺, Ho³⁺, Nd³⁺) were doped into NaYF₄ via a high-temperature coprecipitation method, and followed by SiO₂ coating to improve the water dispersibility, resulting in NaYF₄:Tm³⁺, Er³⁺...

Degradation behaviors and in-vivo biocompatibility of a rare earth- and aluminum-free magnesium-based stent

Biodegradable stents can provide scaffolding and anti-restenosis benefits in the short term and then gradually disappear over time to free the vessel, among which the Mg-based biodegradable metal stents have been prosperously developed. In the present study, a Mg-8.5Li (wt.%) alloy (RE- and Al-free) with high ductility (> 40%) was...

Additively manufactured biodegradable porous metals

For the treatment of large bony defects, no perfect solution has been yet found, partially due to the unavailability of ideal bone implants. Additively manufactured (AM) biodegradable porous metals provide unprecedented opportunities to fulfil the requirements for ideal bone implants to be used in such treatments. Firstly, the multi-scale...

Additively manufactured biodegradable porous metals

Partially due to the unavailability of ideal bone substitutes, the treatment of large bony defects remains one of the most important challenges of orthopedic surgery. Additively manufactured (AM) biodegradable porous metals that have emerged since 2018 provide unprecedented opportunities for fulfilling the requirements of an ideal bone...

Additively manufactured biodegradable porous zinc

Additively manufacturing (AM) opens up the possibility for biodegradable metals to possess uniquely combined characteristics that are desired for bone substitution, including bone-mimicking mechanical properties, topologically ordered porous structure, pore interconnectivity and biodegradability. Zinc is considered to be one of the promising...

Biodegradable magnesium matrix composites for bone fixation devices

When a bone is fractured, it loses its structural integrity which makes it unable to bear any mechanical load. Therefore, a broken bone must be supported until it regains its strength to handle the body's movement and weight. A surgical procedure is needed to set a fractured bone. This procedure often involves repositioning the bone fragments...

Biodegradation and mechanical behavior of an advanced bioceramic-containing Mg matrix composite synthesized through in-situ solid-state oxidation

Recent studies have shown great potential of Mg matrix composites for biodegradable orthopedic devices. However, the poor structural integrity of these composites, which results in excessive localized corrosion and premature mechanical failure, has hindered their widespread applications. In this research, an in-situ Powder Metallurgy (PM)...

Additively manufactured biodegradable porous iron

Additively manufactured (AM) topologically ordered porous metallic biomaterials with the proper biodegradation profile offer a unique combination of properties ideal for bone regeneration. These include a fully interconnected porous structure, bone-mimicking mechanical properties, and the possibility of fully regenerating bony defects. Most...

Additively manufactured biodegradable porous magnesium

An ideal bone substituting material should be bone-mimicking in terms of mechanical properties, present a precisely controlled and fully interconnected porous structure, and degrade in the human body to allow for full regeneration of large bony defects. However, simultaneously satisfying all these three requirements has so far been highly...

Mechanical properties and biocompatibility of poly(methyl methacrylate) bone cement containing microencapsulated tissue adhesive

One of the most broadly reported self-healing schemes is that pioneered by White and Sottos et al. in which a polymer matrix is co-embedded with a catalyst and microcapsules containing a reactive healing agent. Although this field has been steadily growing over the past 10 years, little discussion of extension into biomaterials has taken place...