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Wolfkamp, Wouter (author), Meijer, Joyce (author), van Hoeve, Jolanda C. (author), van Erning, Felice (author), de Geus-Oei, L.F. (author), de Hingh, Ignace (author), Veltman, Jeroen (author), Siesling, Sabine (author)Background: In the Netherlands, the COVID-19 pandemic resulted in a temporary halt of population screening for cancer and limited hospital capacity for non-COVID care. We aimed to investigate the impact of the pandemic on the in-hospital diagnostic pathway of breast cancer (BC) and colorectal cancer (CRC). Methods: 71,159 BC and 48,900 CRC...journal article 2024
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van Oossanen, R. (author), Maier, A. (author), Godart, Jérémy (author), Pignol, Jean Philippe (author), Denkova, A.G. (author), van Rhoon, Gerard C. (author), Djanashvili, K. (author)Objective: To investigate the potential of hybrid Pd/Fe-oxide magnetic nanoparticles designed for thermo-brachytherapy of breast cancer, considering their specific loss power (SLP) and clinical constraints in the applied magnetic field. Methods: Hybrid nanoparticles consisting of palladium-core and iron oxide shell of increasing thickness,...journal article 2024
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van Strien-Knippenberg, Inge S. (author), Arjangi-Babetti, Hannah (author), Timmermans, Danielle R.M. (author), Schrauwen, Laura (author), Fransen, M.P. (author), Melles, M. (author), Damman, Olga C. (author)Background: Risk-based breast cancer (BC) screening raises new questions regarding information provision and risk communication. This study aimed to: 1) investigate women’s beliefs and knowledge (i.e., mental models) regarding BC risk and (risk-based) BC screening in view of implications for information development; 2) develop novel...journal article 2024
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Brouwer, Niek (author)The tumor composition of breast cancer determines how tumors behave. Yet, there is a limited understanding of the arrangement of tumor cells in relation to cells in the tumor microenvironment (TME). In this research, we have characterized distance relationships between 324 cell-type pairs in 749 tissue samples of the Molecular Taxonomy of Breast...master thesis 2023
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Engelberts, Rutger (author)With breast cancer being the leading cause of death in the Netherlands, while also being expected to have double the amount of cases in the next ten years, it is vital that treatment is optimised. Over the last decade, research has been done to incorporate mathematical modelling in this process, especially in the case of HER2+ breast cancer...master thesis 2023
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Yeh, Haoming (author)During the preoperative planning for breast-conserving surgery, the surgeon makes use of an MRI scan of the breast cancer patient in the prone position to accurately locate the tumour. However, surgery is performed with the patient in the supine position. The surgeon needs to mentally translate the location of the tumour from the prone position...master thesis 2023
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Huele, Iris (author)Purpose Deep inspiration breath hold (DIBH) in photon therapy as well as proton therapy (in free breathing) has been suggested to reduce cardiopulmonary and integral dose without compromising target coverage. The goal is to investigate the dosimetric impact on proton treatment plans of set-up variation and daily anatomy visualized on CBCT prior...master thesis 2023
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Linders, D. G.J. (author), Deken, M. M. (author), van Dam, M. A. (author), Wasser, M. N.J.M. (author), Voormolen, E. M.C. (author), Kroep, J. R. (author), van Dongen, G. A.M.S. (author), Vugts, D. (author), de Geus-Oei, L.F. (author)Background: Approximately 20% of invasive ductal breast malignancies are human epidermal growth factor receptor 2 (HER2)-positive. These patients receive neoadjuvant systemic therapy (NAT) including HER2-targeting therapies. Up to 65% of patients achieve a pathological complete response (pCR). These patients might not have needed surgery....journal article 2023
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Maasland, Anouk (author)The aim of this thesis is to study the dosimetric feasibility of FLASH proton therapy for early-stage breast cancer patients. The biological effect of FLASH is seen under ultra-high dose-rates conditions and is beneficial in the damage to healthy tissue. The FLASH effect could enable the clinical feasibility of definitive radiotherapy for low...master thesis 2022
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van Krimpen, Eline (author)Treatment of early stage breast cancer is generally invasive to a patient's daily life while being treated. Therefore, to diminish the physical and psychological impact during and after recovery, a newly proposed minimally invasive therapy for early-stage breast cancer treatment is proposed. Within this study, this proposed treatment is modelled...master thesis 2022
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Slingerland, Eva (author)HER2+ breast cancer patients suffer from aggressive tumours that often respond well to treatment compared to HER2- patients. Currently, patients are all treated with the same number of anti-tumour treatments, although the required number to eradicate all tumour cells varies between patients. The goal is thus to have an individualised model based...master thesis 2022
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Oudhof, Nathalie (author)Every year, thousands of women are diagnosed with breast cancer. To increase their survival chance and improve the treatment plans available, it is important to accurately predict the patient's response to treatment. For HER2+ breast cancer patients, normally a set number of chemotherapy rounds are administered. However, perhaps some patients...master thesis 2022
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Smilde, Elsemiek (author)Deep learning is a growing field of research and and so is the application of deep learning to the analysis of medical images. Convolutional neural networks are used to diagnose diseases, determine risk of disease development, finding the exact area of abnormalities and and so on. Mammography is an imaging technique, which aims at the early...master thesis 2022
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Middeldorp, Laura (author)When a second tumor arises in the contralateral breast in a patient with a previous or synchronous breast cancer, it is of clinical importance to determine if this tumor is a new unrelated tumor or a metastasis, i.e. clone, of the primary tumor. A new, unrelated tumor may be treated similarly as the first one since treatment was successful,...master thesis 2022
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Willemse, Jeroen (author)Introduction Breast cancer is the most frequently diagnosed type of cancer in women in 2020. Treatment and prognosis of breast cancer is highly dependent on early and accurate diagnosis. In recent years, many studies have evaluated the use of artificial intelligence for the detection of breast cancer in mammographic images. Another imaging...master thesis 2021
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Koopman, Laurence (author)Breast cancer is currently the most prevalent type of cancer. The concluding diagnosis can be obtained with an MRI-guided biopsy. However, due to respiratory movement and human error, the procedure can require multiple attempts, resulting in harmful consequences. To reach the target at the first attempt, the precision of the procedure should be...master thesis 2021
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Sonnya Dellarosa, Sonnya (author)Breast cancer, as one of the main causes of cancer death in the world, requires early detection to increase rate of survival. One idea is to develop a device that women could use at home to perform a regular self-check. Ultrasound is a safe, radiation-free technology that could be used for this device. Ultrasound systems (B-mode) that are...master thesis 2020
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Zhao, Wenzhao (author), Wang, Hongjian (author), Gemmeke, Hartmut (author), van Dongen, K.W.A. (author), Hopp, Torsten (author), Hesser, Jürgen (author)Image reconstruction of ultrasound computed tomography based on the wave equation is able to show much more structural details than simpler ray-based image reconstruction methods. However, to invert the wave-based forward model is computationally demanding. To address this problem, we develop an efficient fully learned image reconstruction...journal article 2020
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Janssen, Ernest (author)Breast cancer is impacting over 1.5 million women each year. Early detection is essential in decreasing the mortality rate. Mammography is currently the golden standard for breast screening. However, this method is not ideal and water-bath ultrasound breast scanning is considered to be a promising screening modality. This type of scanning system...master thesis 2019
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Veitch, D.E. (author), Bochner, Melissa (author), Molenbroek, J.F.M. (author), Goossens, R.H.M. (author), Owen, Harry (author)Introduction There is still a need for competent breast lump detection palpation skills, especially in developing countries. Our goal is to design, develop, and establish a test to determine whether students can, by touch alone, identify and discriminate between a range of different simulated lesions at different adiposity levels. Methods...journal article 2019