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van Unen, Vincent (author), Ouboter, Laura F. (author), Li, Na (author), Schreurs, Mette (author), Abdelaal, T.R.M. (author), Kooy-Winkelaar, Yvonne (author), Beyrend, Guillaume (author), Höllt, T. (author), Maljaars, P. W.Jeroen (author), Mearin, M. Luisa (author), Mahfouz, A.M.E.T.A. (author), Witte, Anne M.C. (author), Clemens, Cornelis H.M. (author), Abraham, Sunje (author), Escher, Johanna C. (author), Lelieveldt, B.P.F. (author), Pascutti, M. Fernanda (author), van der Meulen – de Jong, Andrea E. (author), Koning, Frits (author)Chronic intestinal inflammation underlies inflammatory bowel disease (IBD). Previous studies indicated alterations in the cellular immune system; however, it has been challenging to interrogate the role of all immune cell subsets simultaneously. Therefore, we aimed to identify immune cell types associated with inflammation in IBD using high...journal article 2022
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Suwandi, Jessica S. (author), Laban, Sandra (author), Vass, Kincsὅ (author), Joosten, Antoinette (author), van Unen, Vincent (author), Lelieveldt, B.P.F. (author), Höllt, T. (author), Zwaginga, Jaap Jan (author), Nikolic, Tatjana (author), Roep, Bart O. (author)Induction of antigen-specific regulatory T cells (Tregs) in vivo is the holy grail of current immune-regulating therapies in autoimmune diseases, such as type 1 diabetes. Tolerogenic dendritic cells (tolDCs) generated from monocytes by a combined treatment with vitamin D and dexamethasone (marked by CD52<sup>hi</sup> and CD86<sup>lo</sup>...journal article 2019
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Abdelaal, T.R.M. (author), van Unen, Vincent (author), Höllt, T. (author), Koning, Frits (author), Reinders, M.J.T. (author), Mahfouz, A.M.E.T.A. (author)Mass cytometry by time-of-flight (CyTOF) is a valuable technology for high-dimensional analysis at the single cell level. Identification of different cell populations is an important task during the data analysis. Many clustering tools can perform this task, which is essential to identify “new” cell populations in explorative experiments....journal article 2019
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Beyrend, Guillaume (author), van der Gracht, Esmé (author), Yilmaz, Ayse (author), van Duikeren, Suzanne (author), Camps, Marcel (author), Höllt, T. (author), Vilanova Bartroli, A. (author), van Unen, Vincent (author), Koning, Frits (author), de Miranda, Noel F. C. C. (author), Arens, Ramon (author), Ossendorp, Ferry (author)Background: The clinical benefit of immunotherapeutic approaches against cancer has been well established although complete responses are only observed in a minority of patients. Combination immunotherapy offers an attractive avenue to develop more effective cancer therapies by improving the efficacy and duration of the tumor-specific T-cell...journal article 2019
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Redeker, Anke (author), Remmerswaal, Ester B.M. (author), van der Gracht, Esmé T.I. (author), Welten, Suzanne P.M. (author), Höllt, T. (author), Koning, Frits (author), Cicin-Sain, Luka (author), Nikolich-Žugich, Janko (author), ten Berge, Ineke J.M. (author), van Lier, René A. W. (author), van Unen, Vincent (author), Arens, Ramon (author)The relationship between human cytomegalovirus (HCMV) infections and accelerated immune senescence is controversial. Whereas some studies reported a CMV-associated impaired capacity to control heterologous infections at old age, other studies could not confirm this. We hypothesized that these discrepancies might relate to the variability in the...journal article 2018