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Anderson, David M G (author), Kotnala, Ankita (author), Migas, L.G. (author), Patterson, N. Heath (author), Tideman, L.E.M. (author), Ach, Thomas (author), Tortorella, Sara (author), Van de Plas, Raf (author), Curcio, Christine A. (author), Schey, Kevin L. (author)
Introduction: Age related macular degeneration (AMD) causes legal blindness worldwide, with few therapeutic targets in early disease and no treatments for 80% of cases. Extracellular deposits, including drusen and subretinal drusenoid deposits (SDD; also called reticular pseudodrusen), disrupt cone and rod photoreceptor functions and strongly...
journal article 2023
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Tideman, L.E.M. (author), Migas, L.G. (author), Djambazova, Katerina V. (author), Patterson, Nathan Heath (author), Caprioli, Richard M. (author), Spraggins, Jeffrey M. (author), Van de Plas, Raf (author)
The search for molecular species that are differentially expressed between biological states is an important step towards discovering promising biomarker candidates. In imaging mass spectrometry (IMS), performing this search manually is often impractical due to the large size and high-dimensionality of IMS datasets. Instead, we propose an...
journal article 2021