Hydrodynamics of expanded bed adsorption studied through CFD-DEM

The hydrodynamics of the Expanded Bed Adsorption process is studied through simulations combining Computational Fluid Dynamics and the Discrete Element Method. A representative base case is defined, based on process design parameters commonly encountered in literature. Then, 19 other cases are defined, each representing a singular adjustment...

Small, smaller, smallest: Miniaturization of chromatographic process development

Biopharmaceuticals are becoming increasingly important in modern healthcare. Monoclonal antibodies (mAb) are one of the most widely used therapeutic proteins and are important for the treatment of cancer and autoimmune diseases, among others. After cell culture there are still large amounts of other impurities (e.g. host cell proteins) in...

Automation and miniaturization: Enabling tools for fast, high-throughput process development in integrated continuous biomanufacturing

Process development in the biotech industry leads to investments around hundred of millions of dollars. It is important to mitigate costs without neglecting the quality of process development. Biopharmaceutical process development is important for companies to develop new processes and be first to market, improve a pre-established process, or...

Recent advances in techniques for flavor recovery in liquid food processing

Recovery of volatile flavor-active aroma compounds which are key components of processed liquid food streams is of utmost concern to food industry, as these compounds contribute to the quality of the final product. This review paper highlights the recently published research on different techniques that can be applied for recovery of the key...